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Extramural Funding Opportunities

The following is a list of currently open non-limited extramural funding opportunties. Listings are generally updated in batches on a monthly basis. Entries are ordered by posting date, with most recent postings first. All funding opportunities are removed from this list once their final application due date has passed.
  

Posted April 16, 2014

2015 Vilcek Prizes for Creative Promise in Biomedical Science

Application Due Date(s):  June 10, 2014

How to Apply: A written application, professional résumé, list of publications, and letters of recommendation are required. Eligibility requirements and a link to the online application can be found at Vilcek.org.

Description: The Vilcek Foundation is seeking applications for the 2015 Vilcek Prizes for Creative Promise in Biomedical Science. Three foreign-born biomedical scientists will be selected to receive the prizes, each including a cash award of $50,000.

Established in 2009, the Vilcek Prizes for Creative Promise raise public awareness of the key role foreign-born researchers play in sustaining the leadership position of the United States in the sciences; the prizes also serve to support younger scientists who have distinguished themselves early in their careers.

Researchers in all fields of biomedical science are encouraged to apply. Applicants must have been born abroad, be naturalized citizens or permanent residents of the United States, hold a doctoral degree, intend to pursue a career in the United States, and be no more than 38 years old as of December 31, 2014. In addition, they must also hold a full-time independent position at an academic institution or other organization. 

Prostate Cancer Foundation 2014 Movember-PCF Global Treatment Sciences (GTSN) Challenge Award

Application Due Date(s): April 30, 2014

How to Apply: Download the PDF here

Description: The Prostate Cancer Foundation (PCF) is pleased to announce a Request for Applications for metastatic prostate cancer. This award focuses on funding Treatment Sciences: Investigations of new ideas in man or laboratory support of a high impact clinical investigation with a high probability of near-term patient benefit. High risk, currently unfunded projects are most desired.

This award provides up to $1 million dollars per team over a period of two years and will cover direct costs only.

Ovarian Cancer Research Fund 2015 Program Project Development Grant

Application Due Date(s): Letter of Intent due May 6, 2014 / Full proposal due August 1, 2014

How to Apply: Download the PDF here. All LOI’s must be submitted via the ProposalCENTRAL website (https://proposalcentral.altum.com/).

Description: The purpose of this program is to provide funds for ovarian cancer research projects that may involve several investigators within one institution or collaborations between groups in multiple institutions. Applications that are creative, original, and hold the most promise in the areas of screening and early detection, etiology and prevention, molecular therapeutics, cancer biology and genetics are favorable.

The Ovarian Cancer Research Fund will award $300,000 annually for three years. Award recipients are required to submit annual progress reports (narrative and financial) throughout the award cycle. 

Ovarian Cancer Research Fund 2015 Liz Tilberis Early Career Award 

Application Due Date(s): Letter of Intent due May 6, 2014 / Full proposal due August 1, 2014

How to Apply: Download the PDF here. All LOI’s must be submitted via the ProposalCENTRAL website (https://proposalcentral.altum.com/).

Description: The Liz Tilberis Early Career Award is directed towards junior faculty with a strong commitment to an investigative career in the field of ovarian cancer research. The intent of these awards is to support a substantial time commitment to research and academic endeavors in ovarian cancer. The selection committee will favorably consider applications that are creative, original, and hold the most promise in the areas of early detection, prevention, treatment, and translational ovarian cancer research.

The Liz Tilberis Early Career Award will provide funds of $150,000 per year for three years. The investigator and institution must certify that at least 75% of the scholar’s time will be dedicated to ovarian cancer research. Award recipients will be required to submit annual progress reports (narrative and financial) throughout the award cycle.

Ovarian Cancer Research Fund 2015 Ann Schreiber Mentored Investigator Award

Application Due Date(s): Letter of Intent due May 6, 2014 / Full proposal due August 1, 2014

How to Apply: Download the PDF here. All LOI’s must be submitted via the ProposalCENTRAL website (https://proposalcentral.altum.com/).

Description: This award provides funds for trainees who are working under the supervision of a mentor who is a recognized leader in the field of ovarian cancer research, or relevant area. The selection committee will consider the strength of the research environment and project proposal, the trainee’s prior academic track record, and the likelihood of his/her pursuing a research career dedicated to ovarian cancer. The proposed research plan should have sufficient scientific depth to potentially lead to publication of results in high quality journals. Ideally, the project proposed should be one that the trainee’s mentor believes will advance the overall scientific objectives of the group.

The Ann Schreiber Mentored Investigator Award provides a total of $75,000, to be used over one or two years. Although the trainee may take part in some non-research activities (e.g. class work, clinical activities) at least 90% effort should be devoted to research during the tenure of the OCRF award. IRB/IACUC approval will be verified at time of award (do not include with application).

Lung Cancer Research Foundation 2014 Grant

Application Due Date(s): June 16, 2014

How to Apply: Download the PDF here

Description: The Lung Cancer Research Foundation's grant program provides critical seed support for cutting-edge scientific research on all cancers of the lung. The LCRF believes that this type of support can build proof of concept for researchers to apply for additional grant funding from universities and public sources. Lung cancer projects can be focused on basic science, translational research, clinical research, supportive care, and quality of care/outcomes.

This award provides up $50,000 for one year. All applicable costs including indirect/overhead costs must be included as part of requested budget total. Personnel budget lines must not account for more than 15% of total request. Funds may not be used for direct patient care costs that could be reimbursed from other sources.

 

Posted March 4, 2014

Alex’s Lemonade Stand Foundation (ALSF) 'A' Awards

Application Due Date(s): May 23, 2014

How to Apply: Download the PDF here

Description: This grant is designed for early career scientists who want to establish their career in pediatric oncology research. The ideal applicant has an original project that is not currently funded. The goal is to advance research that will lead to new treatments and cures impacting children with cancer.

The ALSF’s ‘A’ Award provides $150,000 a year for three years. In addition, the ‘A’ Award provides reference books to enhance the recipient’s personal pediatric oncology library, up to $10,000 in equipment to enhance lab/project work, and registration fees for one educational course or event. Indirect costs are not allowed.

Alex’s Lemonade Stand Foundation (ALSF) Reach Award 

Application Due Date(s): May 30, 2014

How to Apply: Download the PDF here

Description: The purpose of the Reach Award is to advance ALSF’s mission to find cures and better treatments for childhood cancers by providing support to move hypothesis-driven research into the clinic. The Reach Award seeks to remove some of the barriers of moving a study from the pre-clinical arena into a clinical trial. Thus, the goal of this award is to support selected “late translational” studies needed to ultimately initiate a clinical trial. Preference will be given to those research projects which, if funded, will result in the initiation of a clinical trial within two to three years.

The Reach Award provides a maximum budget of $125,000 a year for two years in total costs. Budget items may include salary (maximum of 10 percent of grant per key investigator), fringe, travel, supplies and small pieces of equipment (less than $5,000). Indirect costs are not allowed. 

Multiple Myeloma Research Foundation (MMRF) 2014 Research Fellow Award 

Application Due Date(s): April 22, 2014

How to Apply: Download the PDF here

Description: The Multiple Myeloma Research Foundation (MMRF) is seeking to support researchers at the post doctorate/medical fellow or junior faculty levels working under the supervision or guidance of a research mentor in the multiple myeloma field. The goal of this initiative is to help support young investigators to begin their studies in the field of multiple myeloma while advancing the understanding of myeloma disease biology, treatment and drug resistance.

This award provides up to $75,000 for one year. This includes up to 10 percent in indirect costs.    

American Society of Hematology Scholar Award

Application Due Date(s): Letter of Intent due May 1, 2014 / Application due August 1, 2014

How to Apply: Visit the website here

Description: The ASH Scholar Award provides funding to support hematologists who have chosen career in research by providing partial salary or other support during that critical period required for completion of training and achievement of status as an independent investigator. This award supports both basic/translational research and clinical research.

This award provides a maximum of $100,000 for fellow scholars and $150,000 for junior faculty scholars over a two- to three-year period, with an annual maximum of $50,000 for fellows and $75,000 for junior faculty. Up to 15 percent of the award may be (but is not required to be) used for benefits, including medical and dental insurance, life insurance, and retirement benefits. 

     

Posted February 24, 2014

V Scholar Award

Application Due Date(s):  Letter of Intent Due February 12, 2014 / Full Application Due April 23, 2014

How to Apply: The V Foundation (click here) has invited the JCCC to nominate one individual for the opportunity. If you are interested in applying, you must submit a one page proposal and biosketch to Nancy Presseau at npresseau@mednet.ucla.edu by Monday, March 10, 2014.

Description: On behalf of the Board of Directors and the Scientific Advisory Committee of The V Foundation for Cancer Research, JCCC members are invited to submit a research project for funding consideration to receive a V Scholar grant. Funding is available for laboratory-based fundamental and translational research. Each grant will total $200,000, and is given in two annual installments.  

Researchers who have secured their own RO1 funding (or similar level of independent support) are not eligible for this award. Applicants with institutional or KO8 awards are eligible.

 

Posted January 30, 2014

Bladder Cancer Advocacy Network (BCAN) 2014 Bladder Cancer Research Innovation Award

Application Due Date(s):  Letter of Intent Due February 12, 2014 / Full Application Due April 23, 2014

How to Apply: Visit the website here

Description: The Bladder Cancer Research Innovation award seeks to support exceptionally novel and creative projects with great potential to produce breakthroughs in the management of bladder cancer. The proposed research may be basic, translational, clinical or epidemiological and must have direct applicability and relevance to bladder cancer. New ideas and innovative approaches may include, but are not limited to, those that utilize novel theoretical concepts, approaches or methodologies, instrumentation, or interventions. Proposals for innovative projects that will develop preliminary data necessary to prepare and submit a competitive research grant application to a major funding agency are encouraged.

This award provides $150,000 a year for two years for direct research related expenses. The subsequent year of funding is dependent on approval after a one year progress report has been submitted and reviewed by BCAN.

 

Posted January 21, 2014

2014 Investigator-Initiated Grant

Application Due Date(s):  Letter of Intent Due January 27, 2014 / Full Application Due May 14, 2014

How to Apply: Visit the website here

Description: The American Institute for Cancer Research Grant Program is dedicated to funding research on cancer prevention, treatment and survival through food, nutrition, physical activity and weight management (body fatness). Grant applications must be clearly related to at least one of AICR’s research priorities and adhere to AICR’s general research principles. Preference will be given to applications that have direct relevance to human cancer.

These awards are generally made for $75,000 a year for two years plus 10 percent indirect costs. A limited number of special Investigator-Initiated Grants will also be made for $75,000 a year for three years plus 10 percent indirect costs. These three-year grants will be awarded to support the start-up of epidemiologic or intervention studies that require additional time.

   

Posted December 20, 2013

NIH Solicitation of Assays for High Throughput Screening (HTS) to Discover Chemical Probes

Application Due Date(s): September 8, 2014

How to Apply: Visit the website here

Description: This Funding Opportunity Announcement (FOA) encourages investigators to form collaborations with an established academic, nonprofit, or commercial high throughput screening (HTS) facility that has the requisite expertise and experience to implement HTS-ready assays for the discovery and development of small molecule chemical probes.

Through this FOA, NIH wishes to stimulate research in 1) discovery and development of novel, small molecules for their potential use in studying disease treatment relevant to the missions of the participating NIH Institutes, and 2) discovery and/or validation of novel, biological targets that will inform studies of disease mechanisms. Emphasis will be placed on assays that provide new insight into important disease targets and processes.

NIH Solicitation of Validated Hits for the Discovery of in vivo Chemical Probes

Application Due Date(s): September 8, 2014

How to Apply: Visit the website here

Description: This Funding Opportunity Announcement (FOA) intends to support investigators who have interest and capability to join efforts for the discovery of in vivo chemical probes. It is expected that applicants will have in hand the starting compounds (“validated hits”) for chemical optimization and bioassays for testing new analog compounds.

Through this FOA, NIH wishes to stimulate research in 1) discovery and development of novel, small molecules for their potential use in studying disease treatment relevant to the missions of the participating NIH Institutes, and 2) discovery and/or validation of novel, biological targets that will inform studies of disease mechanisms. Emphasis will be placed on assays that provide new insight into important disease targets and processes.

   

Posted December 18, 2013

American Cancer Society Research Professor Grant

Application Due Date(s): February 1, 2014 letter of intent due / April 1, 2014 application due

How to Apply: Visit the website here

Description: This grant provides funding to mid-career investigators who have made seminal contributions that have changed the direction of basic cancer research. It is expected that these investigators will continue to provide leadership in their research area.

This grant awards up to $80,000 a year for up to five years. Indirect costs are not allowed.

American Cancer Society Clinical Research Professor Grant

Application Due Date(s): February 1, 2014 letter of intent due / April 1, 2014 application due

How to Apply: Visit the website here

Description: This grant provides funding for established investigators in mid-career who have made seminal contributions in areas of cancer control that have changed the direction of clinical, psychosocial, behavioral, health policy or epidemiologic cancer research. It is expected that these investigators will continue to provide leadership in their research area. The award also may be used to support similarly qualified individuals who are dedicated to bringing advances in basic sciences into the clinical arena and to articulating clinical problems for basic research scientists.

This grant awards up to $80,000 a year for up to five years. Indirect costs are not allowed.

     

Posted September 13, 2013

Alex’s Lemonade Stand Foundation (ALSF) 2014 Innovation Award

Application Due Date(s): Letter of Intent due November 11, 2013 / Full application due March 30, 2014

How to Apply: For complete details on how to apply and eligibility requirements, download the PDF 

Description: This award provides seed funding for researchers with a novel approach to pediatric cancer scientific investigation. This may represent a change in research direction and/or an innovative new idea that moves away from an investigator’s prior research. The Innovation Award supports research proposals to be carried out by investigators who are already established, have a track record of peer=reviewed publications and evidence of successfully competing for substantial extramural funding in other areas.

The Innovation Award provides $125,000 a year for two years.  

 

Posted February 16, 2012

PHS 2012-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])

ID: PA-12-089

Application Due Date(s): Standard dates apply (see website)

How to Apply: Available on website: http://grants.nih.gov/grants/guide/pa-files/PA-12-089.html

Description: This Funding Opportunity Announcement (FOA) issued by the National Institutes of Health (NIH) invites eligible United States small business concerns (SBCs) to submit Small Business Technology Transfer (STTR) grant applications. United States SBCs that have the research capabilities and technological expertise to contribute to the R&D mission(s) of the NIH awarding components identified in this FOA are encouraged to submit STTR grant applications in response to identified topics.

New Technologies for Viral Hepatitis SBIR (R43/R44)

ID: PA-12-090

Application Due Date(s): Standard dates apply (see website)

How to Apply: See website at http://grants.nih.gov/grants/guide/pa-files/PA-12-090.html 

Description: The purpose of this Funding Opportunity Announcement (FOA) is to encourage Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to respond to the Combating the Silent Epidemic of Viral Hepatitis: U.S. Department of Health and Human Services Action Plan for the Prevention, Care and Treatment of Viral Hepatitis (Viral Hepatitis Action Plan) which was released on May 12, 2011 (http://www.hhs.gov/ash/initiatives/hepatitis/). SBCs are encouraged to propose SBIR grant applications to develop resources, research tools, instrumentations, biomarkers, devices, drugs or new and innovative approaches to diagnosis, monitoring, management, treatment and prevention of viral hepatitis and viral hepatitis associated liver disease.

New Technologies for Viral Hepatitis STTR (R41/R42)

ID: PA-12-091

Application Due Date(s): Standard dates apply (see website)

How to Apply: http://grants.nih.gov/grants/guide/pa-files/PA-12-091.html

Description: The purpose of this Funding Opportunity Announcement (FOA) is to encourage Small Business Innovation Research (STTR) grant applications from small business concerns (SBCs) that propose to respond to the Combating the Silent Epidemic of Viral Hepatitis: U.S. Department of Health and Human Services Action Plan for the Prevention, Care and Treatment of Viral Hepatitis (Viral Hepatitis Action Plan) which was released on May 12, 2011 (http://www.hhs.gov/ash/initiatives/hepatitis/). SBCs are encouraged to propose STTR grant applications to develop resources, research tools, instrumentations, biomarkers, devices, drugs or new and innovative approaches to diagnosis, monitoring, management, treatment and prevention of viral hepatitis and viral hepatitis associated liver disease.

Exploratory/Developmental Grants Program for Basic Cancer Research in Cancer Health Disparities (R21)

ID: PAR-12-094

Application Due Date(s): Standard dates apply (see website)

How to Apply: http://grants.nih.gov/grants/guide/pa-files/PAR-12-094.html

Description: Through this Funding Opportunity Announcement (FOA), the Center to Reduce Cancer Health Disparities (CRCHD) and the Division of Cancer Biology (DCB), at the National Cancer Institute (NCI), invite grant applications from investigators interested in conducting basic research studies into the biological causes and mechanisms of cancer health disparities. These awards will support pilot and feasibility studies, development and testing of new methodologies, secondary data analyses, and innovative mechanistic studies that investigate biological/genetic bases of cancer health disparities. This FOA is also designed to aid and facilitate the growth of a nationwide cohort of scientists with a high level of basic research expertise in cancer health disparities research and to provide resources for those investigators that may need additional support on their path to successfully compete for R01 funding in basic mechanistic research in understanding cancer health disparities.

Basic Cancer Research in Cancer Health Disparities (U01)

ID: PAR-12-095

Application Due Date(s): November 20, 2013; June 20, 2014; November 20, 2014 , by 5:00 PM local time of applicant organization.

How to Apply: http://grants.nih.gov/grants/guide/pa-files/PAR-12-095.html

Description: Through this Funding Opportunity Announcement (FOA), the Center to Reduce Cancer Health Disparities (CRCHD), the Division of Cancer Biology (DCB) and Division of Cancer Prevention (DCP), at the National Cancer Institute (NCI), encourage grant applications from investigators interested in conducting basic, mechanistic research into the biologic/genetic causes of cancer health disparities. These cooperative agreement research awards (U01) will support innovative studies designed to investigate biological/genetic bases of cancer disparities, and may include the development and testing of new methodologies and models, secondary data analyses, and mechanistic studies of identified biological factors associated with cancer disparities, including those related to basic research in prevention strategies. This FOA is also designed to aid and facilitate the development of a nationwide cohort of scientists with a high level of basic research expertise in cancer health disparities research who can develop resources and tools, such as biospecimens, cell lines and methods that are necessary to conduct basic research in cancer health disparities.

 

Posted Dec. 5, 2011

Basic research on decision making: Cognitive, affective, and developmental perspectives (R01)

ID: RFA-MH-12-130

Application Due Date(s): Not specified

How to Apply: The best way for you to receive additional guidance is to send a draft Specific Aims page to Dr. Janine Simmons, OppNet’s leader for this RFA, at janine.simmons@nih.gov.

Description: The core goal of this RFA is to increase investigations into decision-making, across multiple levels of analysis. Applications that respond to this FOA are expected to propose projects that will further our understanding of the basic behavioral and social mechanisms and processes involved in decision making, and contribute to unifying scientific inquiry across a wide range of biological, behavioral, and social science disciplines that examine judgment and decision making. The only firm limitation is that the project fall within the scope of basic behavioral and social science research (b-BSSR), as described here http://oppnet.nih.gov/about-faqs.asp.

Small Grants Program for Cancer Epidemiology (R03)

ID: PAR-12-039

Application Due Date(s): July 23, 2013; November 19, 2013; March 18, 2014; July 22, 2014; November 18, 2014, by 5:00 PM local time of applicant organization.

How to Apply: http://grants.nih.gov/grants/guide/pa-files/PAR-12-039.html

Description: This funding opportunity announcement (FOA), issued by the National Cancer Institute (NCI), encourages the submission of Small Research Grant (R03) applications for research on cancer etiology and epidemiology. The overarching goal of this FOA is to provide support for pilot projects, testing of new techniques, secondary analyses of existing data, development and validation of measurement methods, linkage of genetic polymorphisms with other variables related to cancer risk, and development of innovative projects for more comprehensive research in cancer etiology and epidemiology.

Using the NIH Small Research Grant (R03) funding mechanism, this FOA focuses on different types of projects including, but not limited to: (1) pilot and feasibility studies; (2) secondary analysis of existing data; (3) small, self-contained research projects; (4) development of research methodology; and (5) development of new research technology. The R03 mechanism is critical for collection of pilot data that can be used for larger grant applications such as the Research Project Grant Mechanism (R01). R01 studies in cancer epidemiology usually require large sample sizes, complex logistics, extensive fieldwork, acquisition of biospecimens, and, sometimes, the acquisition of sensitive information such as reproductive histories.

Cancer Education Grants Program (R25)

ID: PAR-12-049

Application Due Date(s): Standard dates apply (see schedule)

How to Apply: http://grants.nih.gov/grants/guide/pa-files/PAR-12-049.html

Description: The NIH Research Education (R25) grant mechanism supports creative and innovative research education programs for the development of biomedical, behavioral, and clinical researchers, or for education and outreach on health-related research to a variety of audiences. Research education grants are not typical research instruments. The awards are intended to support institutional educational programs but not research projects. Applications must include a plan to evaluate the educational activities proposed (see Section IV, Evaluation Plan) and a plan for disseminating results (see Section IV, Dissemination Plan). The NCI uses this FOA to support innovative institutional educational programs in the mission area(s) of the National Cancer Institute (http://strategicplan.nci.nih.gov/).

 

Posted Aug. 5, 2011

Center for Inherited Disease Research (CIDR) High Throughput Genotyping and Sequencing Resource Access (X01)

ID: PAR-11-210

How to Apply: http://grants.nih.gov/grants/guide/pa-files/PAR-11-210.html

Application Due Date: Applications are accepted by continuous receipt.

Description: This FOA is seeking projects that show promise of identifying genetic element(s) important to human health and disease. CIDR high-throughput genotyping, sequencing and supporting statistical genetics services are designed to aid the identification of genes that contribute to human health and disease. The services provided through CIDR focus primarily on needs that can’t be readily handled by individual investigator laboratories. CIDR provides the most up-todate platforms and services. This is an NIH-wide initiative that is managed by NHGRI. There should be strong evidence that the project proposed is likely to have the power to detect genetic factors affecting the trait under study. In addition, there should be a clear need for the particular high-throughput service requested. Appropriate projects would include but not be limited to: Human GWAS studies for common human diseases; human and mouse genome-wide linkage analyses, whole genome sequencing, whole-exome and custom-targeted DNA sequencing, analyses of DNA methylation and custom SNP genotyping. Offered through the National Cancer Institute.

Early Phase Clinical Trials in Imaging and Image-Guided Interventions (R21)

ID: PAR-11-216

How to Apply: http://grants.nih.gov/grants/guide/pa-files/PAR-11-216.html

Application Due Date: November 13, 2013; March 13, 2014

Description: This Funding Opportunity Announcement (FOA) is intended to support clinical trials conducting preliminary evaluation of the safety and efficacy of imaging agents, as well as an assessment of imaging systems, image processing, image-guided therapy, contrast kinetic modeling, and 3-D reconstruction and other quantitative tools. As many such preliminary evaluations are early in development, this FOA will provide investigators with support for pilot (Phase I and II) cancer imaging clinical trials, including patient monitoring and laboratory studies. The imaging and Image-guided Intervention (IGI) investigations, if proven successful in these early clinical trials, can then be validated in larger studies through competitive R01 mechanisms, or through clinical trials in the Specialized Programs of Research Excellence (SPOREs), Cancer Center and/or Cooperative Groups.

 

Posted July 6, 2011

Interventions for Health Promotion and Disease Prevention in Native American Populations (R01)

ID: PAR-11-346

How to Apply: http://grants.nih.gov/grants/guide/pa-files/PAR-11-346.html

Application Due Date: May 15, 2014

Description: The purpose of this funding opportunity announcement (FOA) is to develop, adapt, and test the effectiveness of health promotion and disease prevention interventions in Native American (NA) populations. NA populations are exposed to considerable risk factors that significantly increase their likelihood of chronic disease, substance abuse, mental illness, and HIV-infection. The intervention program should be culturally appropriate and promote the adoption of healthy lifestyles, improve behaviors and social conditions and/or improve environmental conditions related to chronic disease, the consumption of tobacco, alcohol and other drugs, mental illness or HIV-infection. The intervention program should be designed so that it could be sustained within the entire community within existing resources, and, if successful, disseminated in other Native American communities. The long-term goal of this FOA is to reduce mortality and morbidity in NA communities. For the purposes of this FOA Native Americans include the following populations: Alaska Native, American Indian, and Native Hawaiian. The term ‘Native Hawaiian’ means any individual any of whose ancestors were natives, prior to 1778, of the area which now comprises the State of Hawaii. 

 

Last updated: 4/16/2014 2:04:08 PM