The following new grants were awarded to JCCC members, announced in January 2012:
Principal Investigator:
Arab, Lenore
Sponsor Name: University of South Carolina
Award Title: Vitamin D and Related Genes, Race and Prostate Cancer Aggressiveness
Principal Investigator: Cloughesy, Timothy
Sponsor Name: Plexxikon Inc.
Award Title: A Phase 2 Study of Orally Administered Plx3397 in Patients With Recurrent Glioblastoma
Principal Investigator: Crooks, Gay M
Sponsor Name: Cal Institute for Regenerative Medicine (CIRM)
Award Title: Forming the Hematopoietic Niche from Human Pluripotent Stem Cells
Principal Investigator: De Vos, Sven
Sponsor Name: "Novella Clinical, Inc.
Award Title: An Extension Study to Investigate the Safety and Durability of Clinical Activity of CAL-101 in Patients with Hematologic Malignancies
Principal Investigator: Garraway, Isla P
Sponsor Name: Margaret E. Early Medical Research Trust
Award Title: Defining the Human Prostate Cellular Hierarchy for Evaluation of the Cell of Origin of Indolent Versus Aggressive Prostate Cancer
Principal Investigator: Heaney, Anthony P
Sponsor Name: Versartis, Inc.
Award Title: A Blinded Placebo Controlled Single Ascending Dose Phase 1 for Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics After Subcutaneous Administration of VRS-317 in Adults With Growth Hormone Deficiency
Principal Investigator: Hecht, J. R
Sponsor Name: Gilead Sciences, Inc.
Award Title: Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of GS-6624 Combined With FOLFIRI as Second Line Treatment for Metastatic KRAS or BRAF Mutant Colorectal Adenocarcinoma That Has Progressed Following a First Line Oxaliplatin- and Fluoropyrimidine-Containing Regimen.
Principal Investigator: Hurvitz, Sara
Sponsor Name: Glaxosmithkline (Merge:Glaxo Welcome/Smith Kline Beacham)
Award Title: A Randomized, Phase III, Open-label Study of Lapatinib Plus Trastuzumab Versus Trastuzumab as Continued HER2 Suppression therapy After Completion of First- or Second-line Trastuzumab Plus Chemotherapy in Subjects with HER2-positive Metastatic Breast Cancer
Principal Investigator: Kheifets, Leeka I
Sponsor Name: Electric Power Research Institute (EPRI)
Award Title: Exploring the Feasibility of Novel Approaches to the Investigation of ELF & Childhood Leukemia
Principal Investigator: Konecny, Gottfried E
Sponsor Name: Pfizer Inc. (Incl Warner-Lamber and Parke-Davis)
Award Title: An Open Label Phase II Study of the Efficacy and Safety of PD0332991 A Selective Inhibitor of the Cyclin Dependent Kinases 4 and 6 in Patients With Recurrent Ovarian Cancer Demonstrating Rb-Proficiency and Low P16 Expression
Principal Investigator: Konecny, Gottfried E
Sponsor Name: Clovis Oncology
Award Title: CDA20120180: Possible Research Collaboration Involving the Testing of the Parp Inhibitor Recaparib in Cancer Cells
Principal Investigator: Lee, Jay M
Sponsor Name: Tragara Pharmaceuticals, Inc.
Award Title: Evaluation of Apricoxib (Selective Cyclooxygenase 2 Inhibition) in Modulating T Regulatory Cells of Patients with Early Stage Non-Small Cell Lung Cancer
Principal Investigator: Marks, Leonard S
Sponsor Name: Pharmanet, Inc.
Award Title: Phase Iii, Active-Controlled, Safety and Efficacy Trial of Oral Testosterone Nudecanoate (Tu) in Hypogonadal Men
Principal Investigator: Marks, Leonard S
Sponsor Name: Mdxhealth SA
Award Title: Detection of Cancer Using Methylated Events in Negative Tissue (Document Study)
Principal Investigator: Martinez, Otoniel M
Sponsor Name: Margaret E. Early Medical Research Trust
Award Title: Microrna (MIRNA) Expression and the Development of B Cell Non-Hodgkin Lymphoma (NHL)
Principal Investigator: Maxwell, Annette
Sponsor Name: University of Washington
Award Title: Alliance for Reducing Cancer Northwest
Principal Investigator: Maynard, Heather
Sponsor Name: Netherlands Organisation for Scientific Research (Netherland
Award Title: Glycopolymers for Protection of Protein Conjugates (Fellow: Erhan Bat)
Principal Investigator: Maynard, Heather
Sponsor Name: NIH Natl Institute of Biomedical Imaging & Bioengineering
Award Title: Stable and Active BFGF-Polymer Conjugates for Wound Healing
Principal Investigator: Mitsuyasu, Ronald T
Sponsor Name: Sangamo Biosciences, Inc.
Award Title: Long-Term Follow-Up of HIV-Infected Subjects Treated with Autologous T-Cells Genetically Modified at the CCR5 Gene by Zinc Finger Nucleases (SB-728-T)
Principal Investigator: Nelson, Stanley F
Sponsor Name: The Guthy-Jackson Charitable Foundation
Award Title: Genome-Wide Association Study of Neuromyelitis Optica
Principal Investigator: Nelson, Stanley F
Sponsor Name: "Avi Biopharma
Award Title: CDA20120072: Discussing Preclinical Development Services Related to the California Institute for Regenerative Medicine (CIRM) Solicitation RFA 10-05 F)
Principal Investigator: Ribas, Antoni
Sponsor Name: Schering-Plough N.J. (Incl Schering-Plough Research Inst.)
Award Title: Phase I Study of Single Agent Mk-3475 in Patients With Progressive Locally Advanced Or Metastatic Carcinoma and Melanoma
Principal Investigator: Shuai, Ke
Sponsor Name: Margaret E. Early Medical Research Trust
Award Title: The Characterization of the PIAS1 Epigenetic Pathway in Tumorigenesis
Principal Investigator: Slamon, Dennis
Sponsor Name: Eli Lilly and Company
Award Title: Preclinical Research Program to Evaluate Potential Translational Science for Eli Lilly: AKT Inhibitor, HER3 Antibody, Dual PI3 Kinase/MTO5 Inhibitor
Principal Investigator: Slamon, Dennis
Sponsor Name: Genentech, Inc.
Award Title: Randomized, Phase II, Multicenter, Double-blind, Placebo-controlled Study Evaluating the Safety and Efficacy of Onartuzumab (Metmab) and/or Bevacizumab in Combination With Paclitaxel in Patients With Metastatic, Triple Negative Breast Cancer
Principal Investigator: Wainberg, Zev
Sponsor Name: Genentech, Inc.
Award Title: A Phase II, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of MEGF0444A Dosed to Progression in Combination with Bevacizumab and Folfox in Patients with Previously Untreated Metastatic Colorectal Cancer
Principal Investigator: Wainberg, Zev
Sponsor Name: Plexxikon Inc.
Award Title: Phase 1 Study to Assess Safety, Pharmacokinetics, and Pharmacodynamics of PLX3397 in Patients With Advanced, Incurable, Solid Tumors in Which the Target Kinases Are Linked to Disease Pathophysiology
Principal Investigator: Wainberg, Zev
Sponsor Name: Gilead Sciences, Inc.
Award Title: Phase 2 Randomized, Double-Blinded, Placebo-Controlled Study to Evaluate the Efficacy and Safety of GS-6624 Combined With Gemcitabine as First Line Treatment for Metastatic Pancreatic Adenocarcinoma
Principal Investigator: Wong, David
Sponsor Name: Fanconi Anemia Research Foundation, Inc.
Award Title: Salivary Biomarkers for Oral Cancer Detection in Fanconi Anemia Patients