The following new grants were awarded to JCCC members, announced in June 2012:
Principal Investigator:
Bower, Julienne
Sponsor Name: NIH/National Cancer Institute
Award Title: Biobehavioral Predictors of Fatigue in Newly-Diagnosed Breast Cancer Patients
Principal Investigator: Chmielowski, Bartosz
Sponsor Name: Incyte Genomics, Inc.
Award Title: Phase 1/2 Randomized, Blinded, Placebo Controlled Study of Ipilimumab in Combination With INCB024360 or Placebo in Subjects With Unresectable or Metastatic Melanoma
Principal Investigator: Cloughesy, Timothy
Sponsor Name: Pharmaceutical Product Development, Inc. (Ppd)
Award Title: Open-label, Phase I, Dose-escalation Study Evaluating the Safety and Tolerability of GDC-0084 Administered to Patients With Progressive or Recurrent High-grade Glioma
Principal Investigator: Cloughesy, Timothy
Sponsor Name: Tocagen, Inc.
Award Title: P1 Ascending Dose Trial of the Safety and Tolerability of Toca 511, a Retroviral Replicating Vector, Administered to Subjects at the Time of Resection for Recurrent High Grade Glioma and Followed by Treatment With Toca FC, Extended-Release 5-FC
Principal Investigator: Cloughesy, Timothy
Sponsor Name: Amgen
Award Title: Phase 1 First-in-Human Study Evaluating Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 595 in Subjects With Recurrent Malignant Glioma Expressing Mutant Epidermal Growth Factor Receptor Variant III (EGFRVIII)
Principal Investigator: De Vos, Sven
Sponsor Name: Abbott Laboratories (Incl. Ross Laboratories)
Award Title: Phase 1b Study Evaluating the Safety and Pharmacokinetics of ABT-199 in Combination With Bendamustine/Rituximab (BR) in Subjects With Relapsed or Refractory Non-Hodgkin's Lymphoma
Principal Investigator: Dorigo, Oliver
Sponsor Name: Charles R. Drew University of Medicine & Science
Award Title: Role of Macrophages in Ovarian Cancer
Principal Investigator: Ellingson, Benjamin
Sponsor Name: American College of Radiology
Award Title: Independent Validation of Functional Diffusion Maps (FDMS) as a Biomarker for Glioblastoma Response to Therapy
Principal Investigator: Ellingson, Benjamin
Sponsor Name: UC/Cancer Research Coordinating Committee (CRCC)
Award Title: Probabilistic Radiographic Atlas of Molecular and Interventional Phenotypes in Human Glioblastoma
Principal Investigator: Eradat, Herbert
Sponsor Name: Celgene Corporation
Award Title: Phase 3 Open-Label Randomized Study to Compare the Efficacy and Safety of Rituximab Plus Lenalidomide (CC-5013) Versus Rituximab Plus Chemotherapy Followed by Rituximab in Subjects With Previously Untreated Follicular Lymphoma. The "RELEVANCE" Trial (Rituximab Lenalidomide Versus Any Chemotherapy)
Principal Investigator: Eradat, Herbert
Sponsor Name: Abbott Laboratories (Incl. Ross Laboratories)
Award Title: Extension Study of Navitoclax (Abt-263) in Subjects with Chronic Lymphocytic Leukemia (CLL)
Principal Investigator: Garon, Edward
Sponsor Name: Immunogen, Inc.
Award Title: Phase 1/2 Study to Assess the Safety and Efficacy of Lorvotuzumab Mertansine in Combination With Carboplatin/Etoposide in Patients With Advanced Solid Tumors Including Extensive Stage Small Cell Lung Cancer Official Title: A Phase 1/2 Study to Assess the Safety and Efficacy of Lorvotuzumab Mertansine (IMGN901) in Combination With Carboplatin/Etoposide in Patients With Advanced Solid Tumors Including Extensive Stage Small Cell Lung Cancer
Principal Investigator: Gasson, Judith
Sponsor Name: Jonsson Cancer Center Foundation
Award Title: AVON Cares for Life
Principal Investigator: Goldman, Jonathan
Sponsor Name: Synta Pharmaceuticals Corp.
Award Title: Phase 1 Study of The HSP90 Inhibitor, Ganetespib (Formerly STA-9090, Administered Twice-Weekly in Patients with Solid Tumors
Principal Investigator: Gomperts, Brigitte
Sponsor Name: Children'S Hospital Corp. (The), Boston, Mass
Award Title: Genetic and Epigenetic Programming of Allergic Airway Inflammation
Principal Investigator: Graeber, Thomas
Sponsor Name: Melanoma Research Alliance
Award Title: Delineating BRAF Inhibitor Resistance Mechanisms Using Proteomic Profiling
Principal Investigator: Graeber, Thomas
Sponsor Name: UC/Cancer Research Coordinating Committee (CRCC)
Award Title: Co-Targeting Genomic Instability and Energy Metabolism in Breast Cancer
Principal Investigator: Heber, David
Sponsor Name: Icon Clinical Research Inc.
Award Title: Effect of Dulaglutide on Major Cardiovascular Events in Patients With Type 2 Diabetes: Researching Cardiovascular Events With a Weekly INcretin in Diabetes (REWIND)
Principal Investigator: Hurvitz, Sara
Sponsor Name: Optimer Pharmaceuticals, Inc.
Award Title: Double-Blind, Randomized Phase II Trial of Active Immunotherapy With Globo H-KLH (OPT-822) In Subjects With Metastatic Breast Cancer
Principal Investigator: Jacobsen, Steven
Sponsor Name: Jane Coffin Childs Memorial Fund
Award Title: Studies of 5.8S Ribosomal RNA Biogenesis and 5-Hydromethylcytosine Mapping
Principal Investigator: Kabbinavar, Fairooz
Sponsor Name: Eisai America, Inc.
Award Title: Open-Label, Multicenter, Phase 1b/2 Study of E7080 Alone, and in Combination With Everolimus in Subjects With Unresectable Advanced or Metastatic Renal Cell Carcinoma Following One Prior VEGF-Targeted Treatment
Principal Investigator: Kheifets, Leeka
Sponsor Name: Electric Power Research Institute (Epri)
Award Title: Asthma and EMF
Principal Investigator: Lai, Albert
Sponsor Name: American Brain Tumor Association
Award Title: Non-Invasive Circulation Free DNA Methylation-Based Biomarkers For Glioma Diagnosis and Surveillance
Principal Investigator: Lane, Timothy
Sponsor Name: UC/Cancer Research Coordinating Committee (CRCC)
Award Title: DCAF4 Is an Adaptor for CUL4:DDB1 Ubiguitin Ligase Activity in Cancer
Principal Investigator: Litwin, Mark
Sponsor Name: American Urological Association Foundation, Inc.
Award Title: Chang, Lynne Ada: Impact of Hospital Transfer on Pediatric Testicular Torsion Outcomes
Principal Investigator: Lo, Roger
Sponsor Name: American Skin Association
Award Title: Rtk Coactivation In B-Raf Inhibitor Resistant Melanomas
Principal Investigator: Lo, Roger
Sponsor Name: The Melanoma Research Foundation
Award Title: Garg, Elisha: Rtk Coactivation in B-RAF Inhibitor Resistant Melanomas
Principal Investigator: Lo, Roger
Sponsor Name: Howard Hughes Medical Institute
Award Title: Garg, Elisha: Rtk Coactivation in B-RAF Inhibitor Resistant Melanomas
Principal Investigator: Memarzadeh, Sanaz
Sponsor Name: Sidney Kimmel Foundation for Cancer Research
Award Title: Kimmel Scholarship Award
Principal Investigator: Memarzadeh, Sanaz
Sponsor Name: Charles R. Drew University of Medicine & Science
Award Title: Preclinical Trial to Assess Effectiveness of PARP Inhibitors in Targeting Endometrial Cancer
Principal Investigator: Memarzadeh, Sanaz
Sponsor Name: Concern Foundation
Award Title: Potential Utility of a PARP Inhibitor in Targeting Endometrial Cancers
Principal Investigator: Memarzadeh, Sanaz
Sponsor Name: UC/Cancer Research Coordinating Committee (CRCC)
Award Title: Site Specific Role of Progesterone Anti-Tumor Actions in Endometrial Cancer
Principal Investigator: Mikkola, Hanna
Sponsor Name: Leukemia and Lymphoma Society (Leukemia Society of America)
Award Title: Transcriptional Mechanisms Establishing Hemogenic Endothelium
Principal Investigator: Nelson, Stanley
Sponsor Name: Guthy-Jackson Charitable Foundation
Award Title: Genome-Wide Association Study of Neuromyelitis Optica
Principal Investigator: Pantuck, Allan
Sponsor Name: Pom Wonderful LLC
Award Title: Novel Mitochondrially Encoded Peptides And Their Interaction with the Naturally Occuring Nutrients in Pomegranate
Principal Investigator: Pietras, Richard
Sponsor Name: UC/Cancer Research Coordinating Committee (CRCC)
Award Title: New Biologic Treatments for Human Pancreatic Cancer
Principal Investigator: Ponce, Ninez
Sponsor Name: Association of Asian Pacific Community Health Organizations
Award Title: Patient-Centered Outcomes Research in Community Health Centers
Principal Investigator: Reiter, Robert
Sponsor Name: Takeda Pharmaceutical Company, Limited
Award Title: Evaluation of Candidate EMTGenes
Principal Investigator: Rettig, Matthew
Sponsor Name: Exelixis, Inc.
Award Title: Phase 3, Randomized, Double-blind, Controlled Trial of Cabozantinib (XL184) Versus Mitoxantrone Plus Prednisone in Men With Previously Treated Symptomatic Castration-resistant Prostate Cancer
Principal Investigator: Ribas, Antoni
Sponsor Name: Phase One Foundation
Award Title: Phase 1 Study of Gene Modified Immune Cells and A Ctla4 Antibody in Patients With Advanced Melanoma
Principal Investigator: Rosen, Lee
Sponsor Name: Vegenics Limited (Australia)
Award Title: Phase I, Open Label, Dose Escalation Study of the VEGF-C Human Monoclonal Antibody VGX-100 Administered by Intravenous Infusion Alone and Co-administered With Bevacizumab in Adult Subjects With Advanced or Metastatic Solid Tumors
Principal Investigator: Rosen, Lee
Sponsor Name: Millennium Pharmaceuticals, Inc.
Award Title: Phase 1 Study of Oral MLN9708 to Assess Drug-Drug Interaction With Ketoconazole, Relative Bioavailability, Food Effect, and Safety and Tolerability in Patients With Advanced Nonhematologic Malignancies, Lymphoma, or Waldenstrom's Macroglobulinemia
Principal Investigator: Rosen, Lee
Sponsor Name: Oncomed Pharmaceuticals, Inc
Award Title: Phase 1 Dose Escalation Study of Omp-18R5 in Subjects with Solid Tumors
Principal Investigator: Schiller, Gary
Sponsor Name: Sanofi-Aventis Group (Incl Sanofi Synthelabo, Aventis Pasteu
Award Title: Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled, 3-Arm Study of SAR302503 in Patients With Intermediate-2 or High-Risk Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis With Splenomegaly
Principal Investigator: Schiller, Gary
Sponsor Name: Astellas Pharma US LLC (Inc. Astellas Pharma, Inc.)
Award Title: Phase 2, Randomized, Open-Label Study of the Safety and Efficacy of Two Doses of Quizartinib (AC220; ASP2689) in Subjects With FLT3-ITD Positive Relapsed or Refractory Acute Myeloid Leukemia (AML)
Principal Investigator: Sloan, Erica
Sponsor Name: NIH/National Cancer Institute
Award Title: Adrenergic Regulation of Tumor Inflammation and Metastatic Dissemination
Principal Investigator: Van Dam, Robert
Sponsor Name: Sofie Biosciences, Inc.
Award Title: Commercialization of a Benchtop Radiosynthesizer for the Production of PET Probes for Imaging of Brain Disorders
Principal Investigator: Wu, Lily
Sponsor Name: U.S. Army/Medical Research Acquisition Activity
Award Title: Disrupting The Pro-Tumorigenic Influences of Tumor-Infiltrating Myeloid Cells by CSF1R Blockade to Augment Androgen Deprivation Therapy in Prostate Cancer
Principal Investigator: Zeng, Gang
Sponsor Name: NIH/National Cancer Institute
Award Title: A+PSA Assay for Improved Prostate Cancer Diagnosis and Risk Assessment