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UCLA's Jonsson Comprehensive Cancer Center
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Small Animal Imaging

Director: Arion Chatziioannou, Ph.D.

Co-Director: Jason Lee, Ph.D. 

Location: 
The Crump Institute for Molecular Imaging
California NanoSystems Institute
2nd floor, Room 2200
Los Angeles, CA 90095-1770 

Telephone:
(310) 794-2224 or (310) 794-2232 (Dr. Waldemar Ladno, Imaging Center)
(310) 825-7137 (Dr. Jason Lee)

Fax:
(310) 206-8975

E-mail: 
ArChatziioann@mednet.ucla.edu 
JasonTLee@mednet.ucla.edu

Equipment

  • Genisys combined microPET/CT scanner (Sofie Biosciences)
  • Inveon microPET scanner (Siemens)
  • Focus 220 microPET scanner (Concorde Microsystems)
  • microCAT II microCT scanner (Imtek)
  • in-house state-of-the-art microCT scanner
  • IVIS Lumina II bioluminescent and fluorescent optical CCD imaging
  • Maestro fluorescent imaging system with NIR imaging and spectral unmixing (CRi)
  • Wizard 3" automatic gamma counter (Perkin Elmer)
  • Cryostat, cryomicrotome and FUJIFILM BAS-500 phosphor imaging system
  • Gilson HPLC with UV/Vis detector, Bioscan Flow-Count radiation detector and fraction collector
  • Adams MHCT II whole blood micro-hematocrit centrifuge
  • Microfuge 22R centrifuge (Beckman Coulter)
  • Tissue culture set-up: biosafety cabinet, cell incubator, microscope, centrifuge

Services

  • MicroPET small animal studies, including tail vein injection in mice, anesthesia, cardiac puncture for blood sampling, animal monitoring and PET imaging, calibration and data reconstruction
  • MicroCAT (CT imaging for rat heads and whole-body mouse imaging)
  • In vivo bioluminescent and fluorescent optical imaging
  • Digital whole-body autoradiography (DWBA)
  • Radiolabeling lab and workspace
  • Animal procedure workspace
  • Biosafety cabinets and fume hoods
  • Data archiving and image display (web-based access)
  • Tissue culture

Recharge Rates

Service

JCCC RATE

PER UNIT

PET/CT Study with FDG $105 Animal
FDG, Fluoride ion imaging probes $45 Dose
FLT, FHBG, FESP, other specialized imaging probe $112 Dose
Radiolabeling (not ncluding cost of radioisotope) $692 Procedure
MicroPET imaging (user-provided probe) $40 Scan
MicroCT imaging $21 Scan
Optical scan (includes luciferin or coelenterazine) $35 Animal
WBDA, Fuji BAS or Microtome usage by investigator $12 Hour
Consultation and protocol development Free  

Operating Policies:

The facility is located in the California NanoSystems Institute and is easily accessible to UCLA Jonsson Comprehensive Cancer Center (JCCC) members. Faculty investigators, research fellows or others who plan to conduct experiments in the resource should contact the Co-Director, Dr. Jason Lee, or the Director, Dr. Arion Chatziioannou, to discuss their experiments. Generally, Dr. Lee will assist with study design, procedures, training and data analysis for interpretation of results. Pilot studies will be performed, if necessary, and the study design perfected. Experiments are generally performed by members of the investigator’s lab, with advice and assistance from the shared resource staff. While Drs. Lee and Chatziioannou remain actively involved in the more complex projects, Dr. Lee oversees the technical quality of all work produced by Small Animal Imaging.

The optical CCD systems are available on a first-come, first-served basis through an online scheduling website. The system requires no supervision once a user is trained; therefore, it can be used at almost any hour of the day. Currently, luciferin and coelenterazine substrates are provided with the service.

 

Last updated: 12/17/2014 4:28:54 PM