Dr. Judith Gasson's research focuses on understanding the processes that regulate the formation of normal blood cells and how those processes are perturbed in blood cell cancers such as leukemias.
Cells of the blood differ greatly in form and function, yet they are all derived from a common pluripotent "stem" cell in the bone marrow. Gasson and her colleagues have adapted a murine embryonic stem cell system to express an inducible form of constitutively active Notch, under conditions that mimic the stem cell niche in vivo. Global gene expression profiling studies have confirmed the importance of the Wnt pathway in maintenance of the primitive phenotype of these cells. Current experiments are focused upon identification and characterization of the transcriptional networks that regulate and maintain these pathways.
Selected Cancer-Related Publications:
Hamidi H, Gustafason D, Pellegrini M, Gasson J. Identification of novel targets of CSL-dependent Notch signaling in hematopoiesis. PLoS One. 2011 May 26;6(5):e20022.
Lynch MR, Gasson JC, Paz H. Modified ES / OP9 co-culture protocol provides enhanced characterization of hematopoietic progeny. J Vis Exp. 2011 Jun 7(52).
Paz H, Lynch MR, Bogue CW, Gasson JC. The homeobox gene Hhex regulates the earliest stages of definitive hematopoiesis. Blood. 2010 Aug 26;116(8):1254-62. Epub 2010 May 14
Zovein AC, Turlo KA, Ponec RM, Lynch MR, Chen KC, Hofmann JJ, Cox TC, Gasson JC, Iruela-Arispe ML. Vascular remodeling of the vitelline artery initiates extravascular emergence of hematopoietic clusters. Blood. 2010 Nov 4;116(18):3435-44. Epub 2010 Aug 10
Ganapati U, Tan HT, Lynch M, Dolezal M, de Vos S, Gasson JC. Modeling notch signaling in normal and neoplastic hematopoiesis: global gene expression profiling in response to activated notch expression. Stem Cells. 2007 Aug;25(8):1872-80. Epub 2007 Apr 26