UCLA's Jonsson Comprehensive Cancer Center : JCCC Member Directory

Steve Horvath, Ph.D., Sc.D.

Affiliation(s):

Professor, Department of Human Genetics, Department of Biostatistics

Member, JCCC Community

Contact Information:

Phone:	(310) 825-9299
Email:	shorvath@mednet.ucla.edu

Scientific Interest(s):

Dr. Steve Horvath and his colleagues are developing statistical and data mining methods that are useful in four domains: methods for finding complex disease genes, FBAT, DNA microarray data analysis, tissue microarray data analysis and sequence properties and gene expression behavior.

Selected Cancer-Related Publications:

Seligson D, Horvath S, Mah V, Yu H, Nooraie F, Tze S, Wang Q, Chia D, Goodglick D, Kurdistani S. A cellular epigenetic signature predicts prognosis in different cancers accepted. Cancer Res. 2007.

Horvath S, Zhang B, Carlson M, Lu KV, Zhu S, Felciano RM, Laurance MF, Zhao W, Shu, Q, Lee Y, Scheck AC, Liau LM, Wu H, Geschwind DH, Febbo PG, Kornblum HI, Cloughesy TF, Nelson SF, Mischel PS. Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a novel molecular target. Proc Natl Acad Sci U S A. 2006 Nov; 103(46):17402-17407.

Mellinghoff IK, Wang MY, Vivanco I, Haas-Kogan DA, Zhu S, Dia EQ, Lu KV, Yoshimoto K, Huang JH, Chute DJ, Riggs BL, Horvath S, Liau LM, Cavenee WK, Rao PN, Beroukhim R, Peck TC, Lee JC, Sellers WR, Stokoe D, Prados M, Cloughesy TF, Sawyers CL, Mischel PS. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med. 2005; 353(19): 2012-24.

Shi T, Seligson D, Belldegrun AS, Palotie A, Horvath S. Tumor classification by tissue microarray profiling: random forest clustering applied to renal cell carcinoma. Mod Pathol. 2005; 18(4): 547-57.

Liu X, Minin V, Huang Y, Seligson DB, Horvath S. Statistical methods for analyzing tissue microarray data. J Biopharm Stat. 2004; 14(3): 671-85.