Dr. Michael Irwin's principal research interests focus on the mechanisms of neuroimmune interactions and the impact of PNI processes on disease including infectious disease, rheumatoid arthritis, cardiovascular disease and substance dependence. He has been the principal investigator of 14 federally funded research awards, including five currently active research awards from the National Institute of Mental Health, National Institute of Alcoholism and Alcohol Abuse, National Institute of Aging, National Institute of Arthritis, and Musculoskeletal Disorders and the National Institute of Drug Abuse.
Irwin's current research topics include "Alcoholism: Sleep and Cytokines in African-Americans," "Depression and Trial of Varicella Vaccine in the Elderly" and "Behavioral Intervention for Herpes Zoster Risk in Aging."
Selected Cancer-Related Publications:
Irwin MR, Olmstead RE, Ganz PA, Haque R. Sleep disturbance, inflammation and depression risk in cancer survivors. Brain Behav Immun. 2013 Mar;30 Suppl:S58-67. Epub 2012 May 24
Bower JE, Garet D, Sternlieb B, Ganz PA, Irwin MR, Olmstead R, Greendale G. Yoga for persistent fatigue in breast cancer survivors: a randomized controlled trial. Cancer. 2012 Aug 1;118(15):3766-75. Epub 2011 Dec 16
Bower JE, Ganz PA, Irwin MR, Kwan L, Breen EC, Cole SW. Inflammation and behavioral symptoms after breast cancer treatment: do fatigue, depression, and sleep disturbance share a common underlying mechanism? J Clin Oncol. 2011 Sep 10;29(26):3517-22. Epub 2011 Aug 8
Bower JE, Ganz PA, Irwin MR, Arevalo JM, Cole SW. Fatigue and gene expression in human leukocytes: increased NF-kappaB and decreased glucocorticoid signaling in breast cancer survivors with persistent fatigue. Brain Behav Immun. 2011 Jan;25(1):147-50. Epub 2010 Sep 18
Miller AH, Ancoli-Israel S, Bower JE, Capuron L, Irwin MR. Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer. J Clin Oncol. 2008 Feb 20;26(6):971-82.