A basic question in cell biology is how a protein reaches its correct location within the cell. Of all the organelles in a mammalian cell, the mitochondrion is the most complex because two membranes must be crossed. In addition to the metabolic role, the mitochondria is a key player in many cellular processes including apoptosis, metal ion homeostasis and aging. Dr. Carla Koehler's research focuses on mitochondrial biogenesis, particularly the mechanism by which proteins are imported into the mitochondrial inner membrane and the process by which defects in mitochondrial protein translocation lead to disease.
Selected Cancer-Related Publications:
Dabir DV, Leverich EP, Kim SK, Tsai FD, Hirasawa M, Knaff DB, Koehler CM. A role for cytochrome c and cytochrome c peroxidase in electron shuttling from Erv1. EMBO J. 2007 Nov 28;26(23):4801-11. Epub 2007 Nov 1.
Hwang DK, Claypool SM, Leuenberger D, Tienson HL, Koehler CM. Tim54p connects inner membrane assembly and proteolytic pathways in the mitochondrion. J Cell Biol. 2007 Sep 24;178(7):1161-75.
Claypool SM, McCaffery JM, Koehler CM. Mitochondrial mislocalization and altered assembly of a cluster of Barth syndrome mutant tafazzins. J Cell Biol. 2006 Jul 31;174(3):379-90.
Rainey RN, Glavin JD, Chen HW, French SW, Teitell MA, Koehler CM. A new function in translocation for the mitochondrial i-AAA protease Yme1: import of polynucleotide phosphorylase into the intermembrane space. Mol Cell Biol. 2006 Nov;26(22):8488-97. Epub 2006 Sep 11.
Koehler CM. New developments in mitochondrial assembly. Annu Rev Cell Dev Biol. 2004;20:309-35.