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Harley Kornblum, M.D., Ph.D.
Harley Kornblum, M.D., Ph.D.

Specialty:

Pediatric Neurology

General Information:

Gender:
Male
Language(s):
English, Spanish

Affiliation(s):

Professor, Department of Psychiatry and Behavioral Sciences
Member, JCCC Cancer and Stem Cell Biology Program Area

Education:

Fellowship:
Pediatrics/Neurology, UCLA School of Medicine, 1991 - 1994
Residency:
Pediatrics, UCLA School of Medicine, 1989 - 1991
Internship:
Pediatrics, UCLA School of Medicine, 1989 - 1990
Medical Degree:
M.D., UC Irvine College of Medicine, 1989
Degree:
Ph.D., UC Irvine, 1986

Certification(s):

Medical Board Certification(s):
Neurology - Child Neurology, American Board of Psychiatry and Neurology, 1997

Contact Information:

Pediatrics:
(310) 825-6185 Information and referral
(310) 206-5737 Admissions
(310) 825-0867 Outpatient appointments
UCLA Children's Health Center Suite 265:
(310) 825-0867 Patient appointments
Pediatric Neurology:
(310) 825-6196 Information
(310) 825-0867 Patient appointments
Pediatric Epilepsy Program:
(310) 825-6196 Information
(310) 825-0867 Patient appointments
Phone:
(310) 794-7866
Email:

Practice Information:

Clinical Interest(s):
General Neurology
Seizure Disorders

Scientific Interest(s):

The work in Dr. Harley Kornblum's lab is directed towards discovering the fundamental biology of nervous system stem cells and how these cells can be used to repair brain and spinal cord injury, as well as how knowledge of stem cells can lead to new treatments for brain tumors.

Kornblum has participated in fundamental research to discover genetic programs of stem cell proliferation and also performed studies of the way that brain tumors may be formed from brain stem cells. His laboratory is an interdisciplinary one, using many methods, including small animal imaging and surgery as well as molecular and cellular techniques.

Selected Cancer-Related Publications:

Nakano I, Dougherty JD, Kim K, Klement I, Geschwind DH, Kornblum HI. Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation. Stem Cells. 2007.

Visnyei K, Tatsukawa KJ, Erickson RI, Simonian S, Oknaian N, Carmichael ST, Kornblum HI. Neural progenitor implantation restores metabolic deficits in the brain following striatal quinolinic acid lesion. Exp Neurol. 2006; 197(2): 465-74.

Horvath S, Zhang B, Carlson M, Lu KV, Zhu S, Felciano RM, Laurance MF, Zhao W, Qi S, Chen Z, Lee Y, Scheck AC, Liau LM, Wu H, Geschwind DH, Febbo PG, Kornblum HI, Cloughesy TF, Nelson SF, Mischel PS. Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target. Proc Natl Acad Sci U S A. 2006; 103(46): 17402-7.

Nakano I, Paucar AA, Bajpai R, Dougherty JD, Zewail A, Kelly TK, Kim KJ, Ou J, Groszer M, Imura T, Freije WA, Nelson SF, Sofroniew MV, Wu H, Liu X, Terskikh AV, Geschwind DH, Kornblum HI. Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. J Cell Biol. 2005; 170(3): 413-27.

Tiwari-Woodruff SK, Kaplan R, Kornblum HI, Bronstein JM. Developmental expression of OAP-1/Tspan-3, a member of the tetraspanin superfamily. J Neurosci Res. 2004; 77(2): 166-73.