Dr. Timothy Lane's research focuses on the interaction of tumor cells with their microenvironment, in particular, the relationship between tumor genetics and the recruitment of host derived blood vessels. The lab has developed several tools to study circulating endothelial progenitors and currently is focused on identifying key molecules which regulate the recruitment of these progenitors to sites of tumor growth.
Selected Cancer-Related Publications:
Monvoisin A, Alva JA, Hofmann JJ, Zovein AC, Lane TF, Iruela-Arispe ML. VE-cadherin-CreERT2 transgenic mouse: a model for inducible recombination in the endothelium. Dev Dyn. 2006; 235(12): 3413-22.
Narko K, Zweifel B, Trifan O, Ristimaki A, Lane TF, Hla T. COX-2 inhibitors and genetic background reduce mammary tumorigenesis in cyclooxygenase-2 transgenic mice. Prostaglandins Other Lipid Mediat. 2005; 76(1-4): 86-94.
Lane TF. BRCA1 and transcription. Cancer Biol Ther. 2004; 3(6): 528-33.
Doyle SE, O'Connell RM, Miranda GA, Vaidya SA, Chow EK, Liu PT, Suzuki S, Suzuki N, Modlin RL, Yeh WC, Lane TF, Cheng G. Toll-like receptors induce a phagocytic gene program through p38. J Exp Med. 2004; 199(1): 81-90.
O'Connell RM, Saha SK, Vaidya SA, Bruhn KW, Miranda GA, Zarnegar B, Perry AK, Nguyen BO, Lane TF, Taniguchi T, Miller JF, Cheng G. Type I interferon production enhances susceptibility to Listeria monocytogenes infection. J Exp Med. 2004; 200(4): 437-45.