Dr. Shuo Lin and his colleagues use zebrafish to investigate the molecular mechanisms by which diverse and specialized cell types are developed during the vertebrate embryogenesis. Currently, his laboratory is focusing in two areas. First, they are working to define the genetic pathways underlying hematopoiesis. They are especially interested in identifying those factors that mediate the initial determination and proliferation of hematopoietic stem cells, and progenitor cells for erythroid and lymphoid lineages. Second, they are studying the genetic basis underlying the neural development, focusing on the forebrain and its associated anterior structures. The researchers are also developing new technologies, such as genetic knockout, for zebrafish in order to better address fundamental questions raised in their studies. Systematic screens using genetic and molecular approaches are being carried out to identify key factors involved in hematopoietic and neuronal development of zebrafish. Given that developmental programs are well conserved among vertebrate animals, studies in zebrafish should ultimately lead to a better understanding of the molecular and genetic basis underlying human development.
Selected Cancer-Related Publications:
Yang Z, Jiang H, Zhao F, Shankar DB, Sakamoto KM, Zhang MQ, Lin S. A highly conserved regulatory element controls hematopoietic expression of GATA-2 in zebrafish. BMC Dev Biol. 2007; 7(1):97.
Sumanas S, Lin S. Ets1-related protein is a key regulator of vasculogenesis in zebrafish. PLoS Biol. 2006; 4(1):e10.
Wu X, Zhong H, Song J, Damoiseaux R, Yang Z, Lin S. Mycophenolic acid is a potent inhibitor of angiogenesis. Arterioscler Thromb Vasc Biol. 2006; 26(10):2414-6.
Zhong H, Wu X, Huang H, Fan Q, Zhu Z, Lin S. Vertebrate MAX-1 is required for vascular patterning in zebrafish. Proc Natl Acad Sci U S A. 2006; 103(45):16800-5.
Sumanas S, Jorniak T, Lin S. Identification of novel vascular endothelial-specific genes by the microarray analysis of the zebrafish cloche mutants. Blood. 2005; 106(2):534-41.