Dr. Stanley Nelson's laboratory develops technology to facilitate the identification of genes that influence complex, multigenic and quantitative traits in humans. Approaches to these difficult genetic problems are a critical challenge to human genetics and will greatly impact medical practice. In general, solutions to these problems require methods that allow genetic features to be determined at high resolution, on large numbers of individuals, in a cost-effective manner. The Nelson lab is developing highly multiplex means of genetic analysis. In addition, the laboratory studies the genetic causes of glioblastomas using large scale gene expression analysis, alternative splicing analysis and chromosomal loss information, and is developing bioinformatic approaches to identify novel therapeutic targets. The Nelson lab is pursuing the large scale genetic analysis of autism, ADHD and vertigo.
Selected Cancer-Related Publications:
Horvath S, Zhang B, Carlson M, Lu KV, Zhu S, Felciano RM, Laurance MF, Zhao W, Qi S, Chen Z, Lee Y, Scheck AC, Liau LM, Wu H, Geschwind DH, Febbo PG, Kornblum HI, Cloughesy TF, Nelson SF, Mischel PS. Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target. Proc Natl Acad Sci U S A. 2006 Nov; 103(46):17402-7. Epub 2006 Nov 7.
Tso CL, Freije WA, Day A, Chen Z, Merriman B, Perlina A, Lee Y, Dia EQ, Yoshimoto K, Mischel PS, Liau LM, Cloughesy TF, Nelson SF. Distinct transcription profiles of primary and secondary glioblastoma subgroups. Cancer Res. 2006; 66(1): 159-67.
Tso CL, Shintaku P, Chen J, Liu Q, Liu J, Chen Z, Yoshimoto K, Mischel PS, Cloughesy TF, Liau LM, Nelson SF. Primary glioblastomas express mesenchymal stem-like properties. Mol Cancer Res. 2006; 4(9): 607-19.
Freije WA, Castro-Vargas FE, Fang Z, Horvath S, Cloughesy T, Liau LM, Mischel PS, Nelson SF. Gene expression profiling of gliomas strongly predicts survival. Cancer Res. 2004; 64(18): 6503-10.
Welford SM, Gregg J, Chen E, Garrison D, Sorensen PH, Denny CT, Nelson SF. Detection of differentially expressed genes in primary tumor tissues using representational differences analysis coupled to microarray hybridization. Nucleic Acids Res. 1998 Jun; 26(12):3059-65.