Dr. Janet Sinsheimer's research is focused on developing mathematical models for evolution and gene mapping. Her research program involves the development and application of statistical methodology for mapping complex trait and disease genes. Most recently, she has been working on statistical methods for detecting disease genes acting through maternal-fetal genotype incompatibility. She has also developed methods for realistic inference of evolutionary relationships and applied these methods to HIV evolution. Her research in HIV evolution seeks to understand the mechanisms by which HIV evades the immune system.