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JCCC Member Directory

Dennis Slamon, M.D., Ph.D.
Dennis Slamon, M.D., Ph.D.

Specialty:

Cancer/Medical Oncology
Hematology
Hematology/Oncology

General Information:

Gender:
Male
Language(s):
English

Affiliation(s):

Professor, Chief, and Executive Vice Chair for Research, Department of Medicine, Hematology/Oncology
Physician and Director, Department of Surgery, Surgical Oncology, Revlon/UCLA Women's Cancer Research Program
Director, JCCC Clinical/Translational Research
Member, JCCC Signal Transduction and Therapeutics Program Area

Hospital Affiliation(s):

Ronald Reagan UCLA Medical Center
Santa Monica - UCLA Medical Center and Orthopaedic Hospital

Education:

Fellowship:
Hematology/Oncology, UCLA School of Medicine, 1979 - 1981
Residency:
Internal Medicine, University of Chicago Hospitals, 1976 - 1978
Internship:
Internal Medicine, University of Chicago Hospitals, 1975 - 1976
Medical Degree:
M.D., University of Chicago Pritzker School of Medicine, 1975
Degree:
Ph.D., University of Chicago, 1975

Certification(s):

Board Certification(s):
Medical Oncology, American Board of Internal Medicine, 1981
Internal Medicine, American Board of Internal Medicine, 1978

Contact Information:

Phone:
(310) 206-6931 or (310) 206-6909 UCLA Oncology Center information and patient appointments
(888) 662-8252 [(888) ONC-UCLA] UCLA Hematology and Oncology Santa Monica information and patient appointments
(310) 829-5471 UCLA Hematology and Oncology Santa Monica information
(310) 825-1412 Dumont-UCLA Liver Cancer Center information and referral
(310) 206-3748 Dumont-UCLA Liver Cancer Center referring physician
Email:

Practice Information:

Clinical Interest(s):
Breast
Ovarian Cancer

Scientific Interest(s):

For 12 years, Dr. Dennis Slamon and his colleagues conducted clinical and laboratory research that led to the development of the breast cancer drug Herceptin. The drug targets a specific genetic alteration found in about 30 percent of breast cancer patients. In 1998, the U.S. Food and Drug Administration approved the use of the Herceptin monoclonal antibody for treatment of advanced breast cancer. Slamon's research proved a relationship between the gene HER-2/neu, which encodes a tyrosine kinase, and a particularly aggressive form of breast cancer. He continues to place research as one of his top priorities, and is currently investigating the effectiveness of Herceptin in newly diagnosed breast cancer patients. Slamon is also working to develop new treatments for women with breast and ovarian cancers.

Selected Cancer-Related Publications:

Britten CD, Kabbinavar F, Randolph Hecht J, Bello CL, Li J, Baum C, Slamon D, Hecht JR. A phase I and pharmacokinetic study of sunitinib administered daily for 2 weeks, followed by a 1-week off period. Cancer Chemother Pharmacol. 2007.

Finn RS, Dering J, Ginther C, Wilson CA, Glaspy P, Tchekmedyian N, Slamon DJ. Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/"triple-negative" breast cancer cell lines growing in vitro. Breast Cancer Res Treat. 2007.

Hinestrosa MC, Dickersin K, Klein P, Mayer M, Noss K, Slamon D, Sledge G, Visco FM. Shaping the future of biomarker research in breast cancer to ensure clinical relevance. Nat Rev Cancer. 2007; 7(4): 309-15.

Jones LW, Haykowsky M, Peddle CJ, Joy AA, Pituskin EN, Tkachuk LM, Courneya KS, Slamon DJ, Mackey JR. Cardiovascular risk profile of patients with HER2/neu-positive breast cancer treated with anthracycline-taxane-containing adjuvant chemotherapy and/or trastuzumab. Cancer Epidemiol Biomarkers Prev. 2007; 16(5): 1026-31.

Munster PN, Britten CD, Mita M, Gelmon K, Minton SE, Moulder S, Slamon DJ, Guo F, Letrent SP, Denis L, Tolcher AW. First study of the safety, tolerability, and pharmacokinetics of CP-724,714 in patients with advanced malignant solid HER2-expressing tumors. Clin Cancer Res. 2007; 13(4): 1238-45.

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