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Jerome A. Zack, Ph.D.
Jerome A. Zack, Ph.D.


Professor, Department of Medicine, Hematology/Oncology
Professor and Vice Chair, Department of Microbiology, Immunology and Molecular Genetics
Director, UCLA Center for AIDS Research (CFAR)
Associate Director, UCLA AIDS Institute
Member, JCCC Tumor Immunology Program Area
Member, JCCC Cancer and Stem Cell Biology Program Area

Contact Information:

(310) 825-0876

Scientific Interest(s):

Dr. Jerome Zack's laboratory concentrates on developing model systems which are more relevant to the pathogenic process in man than are standard in vitro culture approaches, with the eventual goal of using these systems to develop therapeutic strategies for AIDS. Zack and his colleagues are currently concentrating on three major areas of investigation, which include use of the severe combined immunodeficiency (SCID)-hu mouse as an in vivo model for HIV-1-induced pathogenesis and investigating latency mechanisms and therapeutic approaches.

His current studies include factors involved in immune reconstitution following pharmacologic therapy and novel therapeutic approaches including gene therapy, development of novel in vitro culture systems which mimic the in vivo situation and molecular analysis of reverse transcription defects in non-dividing lymphocytes. Zack and his colleagues will continue to develop new model systems and explore existing models to answer important questions regarding the mechanisms associated with HIV disease progression. The members of Zack's laboratory believe that increasing the basic knowledge base regarding pathogenesis will allow a more rational approach to the development of therapeutics to either cure or greatly reduce the morbidity associated with this disease.

Selected Cancer-Related Publications:

Karumbayaram S, Lee P, Azghadi S, Cooper AR, Kohn DB, Pyle A, Clark A, Byrne J, Zack JA, Plath K, Lowry WE. From skin punch biopsy to neurons and glia through a pluripotent cell intermediate under xenogenic-free good manufacturing practice (GMP) conditions. Stem Cells Translational Medicine 1:36-43, 2012.

Kitchen SG, Levin BR, Bristol G, Rezek V, Kim S, Aguilera-Sandoval C, Balamurugan A, Yang OO, Zack JA. In Vivo Suppression of HIV by Antigen Specific T Cells Derived from Engineered Hematopoietic Stem Cells. PLoS Pathog. 2012 Apr;8(4):e1002649. Epub 2012 Apr 12.

Kovochich M, Marsden MD, Zack JA. Activation of latent HIV using drug-loaded nanoparticles. PLoS One. 2011 Apr 5;6(4):e18270.

Marsden MD, Kovochich M, Suree N, Shimizu S, Mehta R, Cortado R, Bristol G, An DS, Zack JA. HIV latency in the humanized BLT mouse. J Virol. 2012 Jan;86(1):339-47. Epub 2011 Nov 9.

Vatakis DN, Koya RC, Nixon CC, Wei L, Kim SG, Avancena P, Bristol G, Baltimore D, Kohn DB, Ribas A, Radu CG, Galic Z, Zack JA. Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):E1408-16. Epub 2011 Nov 28.