Dr. Ohyun Kwon's research interest lies in the development of new methodologies for organic transformations, target-oriented synthesis of biologically important natural compounds and diversity oriented synthesis of natural product-like molecules. Molecules thus built will be employed in the investigation of biologically significant processes.
Selected Cancer-Related Publications:
Cruz D, Wang Z, Kibbie J, Modlin R, Kwon O. Diversity through phosphine catalysis identifies octahydro-1,6-naphthyridin-4-ones as activators of endothelium-driven immunity. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6769-74. Epub 2011 Mar 7
Chan LN, Fiji HD, Watanabe M, Kwon O, Tamanoi F. Identification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-I. PLoS One. 2011 Oct 18;6(10):e26135.
Fan YC, Kwon O. Diversity-oriented synthesis based on the DPPP-catalyzed mixed double-Michael reactions of electron-deficient acetylenes and Beta-amino alcohols. Molecules. 2011 May 5;16(5):3802-25.
Martin TJ, Vakhshori VG, Tran YS, Kwon O. Phosphine-catalyzed Beta'-umpolung addition of nucleophiles to activated a-alkyl allenes. Org Lett. 2011 May 20;13(10):2586-9. Epub 2011 Apr 14
Wang Z, Castellano S, Kinderman SS, Argueta CE, Beshir AB, Fenteany G, Kwon O. Diversity through a branched reaction pathway: generation of multicyclic scaffolds and identification of antimigratory agents. Chemistry. 2011 Jan 10;17(2):649-54. Epub 2010 Nov 9