Dr. Guillaume Chanfreau's research focuses on RNA processing and RNA-protein interactions. Specifically, he and his colleagues are studying RNA processing and RNA recognition by eukaryotic RNase III enzymes and the biogenesis of small ribonucleolar protein particles (snoRNPs). This aspect of Chanfreau's research is the most relevant to cancer, as one of the proteins involved in snoRNPs is mutated in dyskeratosis congenita, a genetic disease leading to gastrointestinal cancers.
Selected Cancer-Related Publications:
Egecioglu DE, Chanfreau G. Proofreading and spellchecking: a two-tier strategy for pre-mRNA splicing quality control. RNA. 2011 Mar;17(3):383-9. Epub 2011 Jan 4
Chanfreau G. InvIGOrating mRNAs during Quiescence. Mol Cell. 2010 May 14;38(3):317-8.
Kawashima T, Pellegrini M, Chanfreau GF. Nonsense-mediated mRNA decay mutes the splicing defects of spliceosome component mutations. RNA. 2009 Dec;15(12):2236-47. Epub 2009 Oct 22
Sayani S, Janis M, Lee CY, Toesca I, Chanfreau GF. Widespread impact of nonsense-mediated mRNA decay on the yeast intronome. Mol Cell. 2008 Aug 8;31(3):360-70.
Oberstrass FC, Lee A, Stefl R, Janis M, Chanfreau G, Allain FH. Shape-specific recognition in the structure of the Vts1p SAM domain with RNA. Nat Struct Mol Biol. 2006; 13(2): 160-7.