Dr. Carolyn Crandall's research focuses on breast cancer risk (e.g., her mammographic density publications) and breast cancer survivorship issues, especially the intersection between breast cancer and menopause (e.g., her publications regarding hot flashes in breast cancer survivors and bone mineral density in breast cancer survivors).
She intends to continue two areas of investigation: first, the influence of breast cancer diagnosis and its therapy on menopause and osteoporosis in breast cancer survivors and secondly, strategies to target women at risk for breast cancer by continuing to study hormonal and genetic determinants of mammographic density. Her overall goals for these two lines of research are to enhance aspects of the quality of life of breast cancer survivors, and to help identify targets for intervention for high-risk women.
Selected Cancer-Related Publications:
Crandall CJ, Aragaki AK, Cauley JA, McTiernan A, Manson JE, Anderson GL, Wactawski-Wende J, Chlebowski RT. Breast tenderness after initiation of conjugated equine estrogens and mammographic density change. Breast Cancer Res Treat. 2012 Feb;131(3):969-79. Epub 2011 Oct 7.
Crandall CJ, Aragaki AK, Cauley JA, McTiernan A, Manson JE, Anderson G, Chlebowski RT. Breast tenderness and breast cancer risk in the estrogen plus progestin and estrogen-alone women's health initiative clinical trials. Breast Cancer Res Treat. 2012 Feb;132(1):275-85. Epub 2011 Nov 1.
Crandall CJ, Aragaki AK, Chlebowski RT, McTiernan A, Anderson G, Hendrix SL, Cochrane BB, Kuller LH, Cauley JA. New-onset breast tenderness after initiation of estrogen plus progestin therapy and breast cancer risk. Arch Intern Med. 2009 Oct 12;169(18):1684-91.
Crandall CJ, Sehl ME, Crawford SL, Gold EB, Habel LA, Butler LM, Sowers MR, Greendale GA, Sinsheimer JS. Sex steroid metabolism polymorphisms and mammographic density in pre- and early perimenopausal women. Breast Cancer Res. 2009;11(4):R51. Epub 2009 Jul 27.
Crandall C, Zheng Y, Karlamangla A, Sternfeld B, Habel L, Oestreicher N, Johnston J, Cauley J, Greendale G. The association between mammographic breast density and bone mineral density. Study of Women's Health Across the Nation. 2007; 17:575-83.