Dr. Lali Medina-Kauwe's research focuses on gene therapy vector development, vector targeting, drug targeting, vector-cell interactions and intercellular trafficking of vectors, viruses and viral proteins. Her current focus is on the targeting of genes, drugs (chemotherapeutic agents and novel toxic compounds), and siRNA to HER2 positive breast cancer.
Selected Cancer-Related Publications:
Agadjanian H, Ma J, Rentsendorj A, Valluripalli V, Hwang JY, Mahammed A, Farkas DL, Gray HB, Gross Z, Medina-Kauwe LK. Tumor detection and elimination by a targeted gallium corrole. Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6105-10. Epub 2009 Apr 2.
Medina-Kauwe LK. "Alternative" endocytic mechanisms exploited by pathogens: new avenues for therapeutic delivery? Adv Drug Deliv Rev. 2007 Aug 10;59(8):798-809. Epub 2007 Jul 5.
Agadjanian H, Weaver JJ, Mahammed A, Rentsendorj A, Bass S, Kim J, Dmochowski IJ, Margalit R, Gray HB, Gross Z, Medina-Kauwe LK. Specific delivery of corroles to cells via noncovalent conjugates with viral proteins. Pharm Res. 2006; 23(2): 367-77.
Rentsendorj A, Xie J, MacVeigh M, Agadjanian H, Bass S, Kim DH, Rossi J, Hamm-Alvarez SF, Medina-Kauwe LK. Typical and atypical trafficking pathways of Ad5 penton base recombinant protein: implications for gene transfer. Gene Ther. 2006; 13(10): 821-36.
Medina-Kauwe LK, Maguire M, Kasahara N, Kedes L. Nonviral gene delivery to human breast cancer cells by targeted Ad5 penton proteins. Gene Ther. 2001 Dec;8(23):1753-61.