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JCCC Member Directory

Jorge R. Barrio, Ph.D.
Jorge R. Barrio, Ph.D.


Distinguished Professor, Department of Molecular and Medical Pharmacology
Elizabeth and Thomas Plott Chair in Gerontology
Member, JCCC Cancer Molecular Imaging Program Area

Contact Information:

(310) 825-4167

Scientific Interest(s):

Dr. Jorge Barrio's research on the development of biological probes focuses on the design, synthesis and validation of positron-emitting and fluorescent labeled probes for enzyme localization and function, presynaptic neurotransmission, postsynaptic receptor interactions, b-amyloid deposition and gene expression.

His investigations have three general aims: 1) to develop biological probes (e.g., radiolabeled fluorinated amino acids, presynaptic dopamine transporter ligand probes) to establish the structural requirements for probing central dopaminergic mechanisms with positron emission tomography (PET); 2) to design PET reporter probes in the development of in vivo non-invasive procedures to quantitate gene expression in animals and humans. Investigate probes for glucose transporters (GLUT-1), dopamine-D2 receptors, aromatic amino acid decarboxylase and thymidine kinase; and 3) to develop specific in vivo probes for b-amyloid plaques for early, non-invasive detection of Alzheimer's disease.

Selected Cancer-Related Publications:

Radu CG, Shu CJ, Nair-Gill E, Shelly SM, Barrio JR, Satyamurthy N, Phelps ME, Witte ON. Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [18F]-labeled 2'-deoxycytidine analog. Nat Med. 2008 Jul;14(7):783-8. Epub 2008 Jun 8

Pan MH, Huang SC, Liao YP, Schaue D, Wang CC, Stout DB, Barrio JR, McBride WH. FLT-PET imaging of radiation responses in murine tumors. Mol Imaging Biol. 2008 Nov-Dec;10(6):325-34. Epub 2008 Aug 1

Kepe V, Barrio JR, Huang SC, Ercoli L, Siddarth P, Shoghi-Jadid K, Cole GM, Satyamurthy N, Cummings JL, Small GW, Phelps ME. Serotonin 1A receptors in the living brain of Alzheimer's disease patients. Proc Natl Acad Sci U S A. 2006; 103(3): 702-7.

Penuelas I, Mazzolini G, Boan JF, Sangro B, Marti-Climent J, Ruiz M, Ruiz J, Satyamurthy N, Qian C, Barrio JR, Phelps ME, Richter JA, Gambhir SS, Prieto J. Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients. Gastroenterology. 2005; 128(7): 1787-95.

Yaghoubi SS, Barrio JR, Namavari M, Satyamurthy N, Phelps ME, Herschman HR, Gambhir SS. Imaging progress of herpes simplex virus type 1 thymidine kinase suicide gene therapy in living subjects with positron emission tomography. Cancer Gene Ther. 2005; 12(3): 329-39.