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JCCC Member Directory

Caius Radu, M.D.
Caius Radu, M.D.

Affiliation(s):

Associate Professor, Department of Molecular and Medical Pharmacology
Member, Crump Institute for Molecular Imaging
Member, JCCC Cancer Molecular Imaging Program Area

Contact Information:

Phone:
(310) 825-0169
Email:

Scientific Interest(s):

The focal research points of Dr. Caius Radu's lab are the development of novel positron emission tomography (PET) probes to image T-lymphocyte activation and inflammation, the evaluation of cancer immunotherapy using PET reporter gene approaches; and the development of non-immunogenic PET reporter gene systems.

Selected Cancer-Related Publications:

Campbell DO, Yaghoubi SS, Su Y, Lee JT, Auerbach MS, Herschman H, Satyamurthy N, Czernin J, Lavie A, Radu CG. Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe. J Biol Chem. 2012 Jan 2;287(1):446-54. Epub 2011 Nov 9

Lee JT, Campbell DO, Satyamurthy N, Czernin J, Radu CG. Stratification of nucleoside analog chemotherapy using 1-(2'-deoxy-2'-18F-fluoro-Beta-D-arabinofuranosyl)cytosine and 1-(2'-deoxy-2'-18F-fluoro-Beta-L-arabinofuranosyl)-5-methylcytosine PET. J Nucl Med. 2012 Feb;53(2):275-80.

Schwarzenberg J, Radu CG, Benz M, Fueger B, Tran AQ, Phelps ME, Witte ON, Satyamurthy N, Czernin J, Schiepers C. Human biodistribution and radiation dosimetry of novel PET probes targeting the deoxyribonucleoside salvage pathway. Eur J Nucl Med Mol Imaging. 2011 Apr;38(4):711-21. Epub 2010 Dec 3

Shu CJ, Campbell DO, Lee JT, Tran AQ, Wengrod JC, Witte ON, Phelps ME, Satyamurthy N, Czernin J, Radu CG. Novel PET probes specific for deoxycytidine kinase. J Nucl Med. 2010 Jul;51(7):1092-8. Epub 2010 Jun 16

Toy G, Austin WR, Liao HI, Cheng D, Singh A, Campbell DO, Ishikawa TO, Lehmann LW, Satyamurthy N, Phelps ME, Herschman HR, Czernin J, Witte ON, Radu CG. Requirement for deoxycytidine kinase in T and B lymphocyte development. Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5551-6. Epub 2009 Dec 31