UCLA's Jonsson Comprehensive Cancer Center : JCCC Member Directory

Gautam Chaudhuri, M.D., Ph.D.

Specialty:

Gynecology

Obstetrics and Gynecology

Reproductive Endocrinology

General Information:

Gender:	Male
Language(s):	English

Affiliation(s):

Distinguished Professor and Executive Chair, Department of Obstetrics and Gynecology

Distinguished Professor, Department of Molecular and Medical Pharmacology

Physician, Department of Obstetrics and Gynecology, General Gynecology Practice, Reproductive Endocrinology and Infertility

Member, ACCESS Department - Molecular and Medical Pharmacology

Member, JCCC Signal Transduction and Therapeutics Program Area

Education:

Residency:	Obstetrics and Gynecology, SUNY Buffalo School of Medicine and Biomed Sciences, 1977 - 1980
Fellowship:	Reproductive Endocrinology, USC School of Medicine, 1975 - 1976
Internship:	Internal Medicine and General Surgery, Safdarjung Hospital, 1965 - 1966
Medical Degree:	M.D., R.G. Kar Medical College, 1964

Contact Information:

Obstetrics and Gynecology:	(310) 794-7274 Patient appointments
General Gynecology Practice:	(310) 794-7274 Patient appointments
Reproductive Endocrinology and Infertility:	(310) 794-7274 Patient appointments
Website:	http://www.uclaobgyn.com
Phone:	(310)-206-6575 (310)-206-2057 Fax
Email:	gchaudhuri@mednet.ucla.edu

Scientific Interest(s):

Dr. Gautam Chaudhuri's research involves utilizing in vivo, in vitro and molecular biology techniques to study physiological and pharmacological problems. He is studying the role of sex steroids in the modulation of endothelial cell function as it relates to control of vascular tone and development of atherosclerosis. Chaudhuri is also exploring factors modulating vascular tone in feto-placental vessels and factors involved in growth of female genital cancer.

Chaudhuri is currently studying the mechanism by which Estradiol and nitric oxide modulate various physiological functions and the signal transduction pathways involved. His major focus is on the effects of estrogens on atherogenesis. He is also studying the signaling mechanisms responsible for cell proliferation and apoptosis by using breast cancer cell lines as the model system.

Selected Cancer-Related Publications:

Pervin S, Tran AH, Zekavati S, Fukuto JM, Singh R, Chaudhuri G. Increased susceptibility of breast cancer cells to stress mediated inhibition of protein synthesis. Cancer Res. 2008 Jun 15;68(12):4862-74.

Pervin S, Singh R, Chaudhuri G. Nitric oxide, N omega-hydroxy-L-arginine and breast cancer. Nitric Oxide. 2008 Sep;19(2):103-6. Epub 2008 Apr 24. Review.

Souter I, Huang A, Martinez-Maza O, Breen EC, Decherney AH, Chaudhuri G, Nathan L. Serum levels of soluble vascular cell adhesion molecule-1, tumor necrosis factor-alpha, and interleukin-6 in in vitro fertilization cycles. Fertil Steril. 2009 May;91(5 Suppl):2012-9. Epub 2008 Sep 7.

Pervin S, Singh R, Hernandez E, Wu G, Chaudhuri G. Nitric oxide in physiologic concentrations targets the translational machinery to increase the proliferation of human breast cancer cells: involvement of mammalian target of rapamycin/eIF4E pathway. Cancer Res. 2007; 67(1): 289-99.

Hayashi T, Esaki T, Sumi D, Mukherjee T, Iguchi A, Chaudhuri G. Modulating role of estradiol on arginase II expression in hyperlipidemic rabbits as an atheroprotective mechanism. Proc Natl Acad Sci U S A. 2006; 103(27): 10485-90.