Dr. Chih-Ming Ho's research focuses on controlling the position of macromolecules, DNA/RNA, proteins and supermolecules for facilitating function processes such as molecular recognition, biochemical reactions and self assembly. As these processes always take place in fluid flows, a key goal is the creation of nano-fluidic technologies to handle nanoscale molecules in microscale reactors. He seeks to understand the interactions between intermolecular force fields and global forces to provide the path for developing efficient nano-fluidic technologies. Ultimately, nano-fluidics form the backbone for a wide spectrum of bio-nano application such as genosensing, drug discovery and health maintenance.
Selected Cancer-Related Publications:
Yu F, Al-Shyoukh I, Feng J, Li X, Liao CW, Ho CM, Shamma JS, Sun R. Control of Kaposi's sarcoma-associated herpesvirus reactivation induced by multiple signals. PLoS One. 2011 Jun 28;6(6):e20998.
Wei F, Liao W, Xu Z, Yang Y, Wong DT, Ho CM. Bio/abiotic interface constructed from nanoscale DNA dendrimer and conducting polymer for ultrasensitive biomolecular diagnosis. Small. 2009 Aug 3;5(15):1784-90.
Sun CP, Usui T, Yu F, Al-Shyoukh I, Shamma J, Sun R, Ho CM. Integrative systems control approach for reactivating Kaposi's sarcoma-associated herpesvirus (KSHV) with combinatory drugs. Integr Biol (Camb). 2009 Jan;1(1):123-30.
Wong PK, Yu F, Shahangian A, Cheng G, Sun R, Ho CM. Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm. Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5105-10. Epub 2008 Mar 20.
Li N, Ho CM. Aptamer-based optical probes with separated molecular recognition and signal transduction modules. J Am Chem Soc. 2008 Feb 27;130(8):2380-1. Epub 2008 Feb 5