Dr. Chih-Ming Ho's research focuses on controlling the position of macromolecules, DNA/RNA, proteins and supermolecules for facilitating function processes such as molecular recognition, biochemical reactions and self assembly. As these processes always take place in fluid flows, a key goal is the creation of nano-fluidic technologies to handle nanoscale molecules in microscale reactors. He seeks to understand the interactions between intermolecular force fields and global forces to provide the path for developing efficient nano-fluidic technologies. Ultimately, nano-fluidics form the backbone for a wide spectrum of bio-nano application such as genosensing, drug discovery and health maintenance.
Selected Cancer-Related Publications:
Wong PK, Yu F, Shahangian A, Cheng G, Sun R, Ho CM. Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm. Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5105-10. Epub 2008 Mar 20.
Wei F, Wang J, Liao W, Zimmermann BG, Wong DT, Ho CM. Electrochemical detection of low-copy number salivary RNA based on specific signal amplification with a hairpin probe. Nucleic Acids Res. 2008 Jun;36(11):e65. Epub 2008 May 17.
Lin Y, Wong TS, Bhardwaj U, Chen JM, Ho CM, McCabe E. Formation of High Electromagnetic Gradient through Particle-based Microfluidic Approach. Journal of Micromechanics and Microengineering. 2007; Vol. 17, pp. 1299 – 1306.
Brough B, Christman KL, Wong TS, Kolodziej CM, Forbes JG, Wang K, Maynard HD, Ho, CM. Surface Initiated Actin Polymerization from Top-down Manufactured Nanopatterns. Soft Matter. 2007; Vol. 3, pp. 541 – 546.
Benahmed AJ, Ho CM. Bandgap-assisted surface-plasmon sensing. Appl Opt. 2007; 46(16): 3369-75.