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JCCC Member Directory

Julian A. Martinez-Agosto, M.D., Ph.D., F.A.C.M.G., F.A.A.P
Julian A. Martinez-Agosto, M.D., Ph.D., F.A.C.M.G., F.A.A.P

Specialty:

Clinical Genetics
Pediatrics

General Information:

Gender:
Male
Language(s):
English

Affiliation(s):

Assistant Professor, Department of Human Genetics and Department of Pediatrics
Associate Director, UCLA Preconception Clinic
Member, JCCC Signal Transduction and Therapeutics Program Area

Hospital Affiliation(s):

Ronald Reagan UCLA Medical Center
Santa Monica-UCLA Medical Center and Orthopaedic Hospital
Stewart and Lynda Resnick Neuropsychiatric Hospital at UCLA

Education:

Fellowship:
Medical Genetics, Cedars-Sinai Medical Center, 2003 - 2005
Residency:
Pediatrics, UCLA School of Medicine, 2001 - 2003
Internship:
Pediatrics, UCLA School of Medicine, 2000 - 2001
Medical Degree:
M.D., Ph.D., Yale School of Medicine, 2000

Certification(s):

Board Certification(s):
Clinical Genetics (M.D.), American Board of Medical Genetics, 2005
Pediatrics, American Board of Pediatrics, 2004

Contact Information:

Phone:
(310) 794-2405
Email:
Website:

Scientific Interest(s):

Dr. Julian Martinez is interested in understanding the common signal transduction pathways across cancer predisposition genetic syndromes, in particular Noonan, Costello, Craniofaciocutaneous, Neurofibromatosis and overgrowth syndromes (Sotos, Beckwith-Wiedemann, Weaver, Simpson-Golabi-Behmel) and their associated malignancies: neuroblastoma, sarcomas, and leukemias.

To this end, Dr. Martinez utilizes Drosophila melanogaster as a model organism in which to study the cellular and genetic mechanisms that lead to oncogenesis due to the signal transduction pathways disrupted in these syndromes.

Selected Cancer-Related Publications:

Tieu KS, Tieu RS, Martinez-Agosto JA, Sehl ME. Stem cell niche dynamics: from homeostasis to carcinogenesis. Stem Cells Int. 2012 Feb 9;2012:367567.

Mondal BC, Mukherjee T, Mandal L, Evans CJ, Sinenko SA, Martinez-Agosto JA, Banerjee U. Interaction between differentiating cell- and niche-derived signals in hematopoietic progenitor maintenance. Cell. 2011 Dec 23;147(7):1589-600.

Chang VY, Quintero-Rivera F, Baldwin EE, Woo K, Martinez-Agosto JA, Fu C, Gomperts BN. B-acute lymphoblastic leukemia and cystinuria in a patient with duplication 22q11.21 detected by chromosomal microarray analysis. Pediatr Blood Cancer. 2011 Mar;56(3):470-3. Epub 2010 Nov 28

Sinenko SA, Mandal L, Martinez-Agosto JA, Banerjee U. Dual role of wingless signaling in stem-like hematopoietic precursor maintenance in Drosophila. Dev Cell. 2009 May;16(5):756-63.

Martinez-Agosto JA, Mikkola HK, Hartenstein V, Banerjee U. The hematopoietic stem cell and its niche: a comparative view. Genes Dev. 2007 Dec 1;21(23):3044-60.