Dr. William Aronson's laboratory and clinical research focuses on translational research in nutrition and prostate cancer. His work focuses on quantity of dietary fat, omega-3 fatty acids from fish oil, caloric restriction, green tea and lycopene. He conducts basic science and clinical research studying the role of these nutritional components for the prevention and treatment of prostate cancer. His present clinical research trials are evaluating a low-fat fish oil diet, a weight loss intervention and green and black tea formulations in men with prostate cancer. This research evaluates both the potential efficacy of these dietary interventions for prostate cancer prevention and treatment and potential serum and tissue biomarkers for a future large-scale nutrition trial in men with prostate cancer.
Aronson also has an extensive clinical research program focusing on multiple important aspects in prostate cancer, including prostate cancer prevention and treatment for early and late stage disease. At present he is conducting a trial evaluating dutasteride for prostate cancer prevention and docetaxel for high risk prostate cancer patients following radical prostatectomy. His clinical research also focuses on predictors of prostate cancer progression in early and late stage prostate cancer. He has also published extensively on obesity and prostate cancer and on the aggressive nature of prostate cancer in African American Men.
Aronson is funded by the National Institutes of Health and the Veterans Administration.
Selected Cancer-Related Publications:
Kobayashi N, Barnard RJ, Henning SM, Elashoff D, Reddy ST, Cohen P, Leung P, Hong-Gonzalez J, Freedland SJ, Said J, Gui D, Seeram NP, Popoviciu LM, Bagga D, Heber D, Glaspy JA, Aronson WJ. Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2. Clin Cancer Res. 2006; 12(15): 4662-70.
Ngo TH, Barnard RJ, Anton T, Tran C, Elashoff D, Heber D, Freedland SJ, Aronson WJ. Effect of isocaloric low-fat diet on prostate cancer xenograft progression to androgen independence. Cancer Res. 2004; 64(4): 1252-4.
Ngo TH, Barnard RJ, Cohen P, Freedland S, Tran C, deGregorio F, Elshimali YI, Heber D, Aronson WJ. Effect of isocaloric low-fat diet on human LAPC-4 prostate cancer xenografts in severe combined immunodeficient mice and the insulin-like growth factor axis. Clin Cancer Res. 2003; 9(7): 2734-43.
Aronson WJ, Glaspy JA, Reddy ST, Reese D, Heber D, Bagga D. Modulation of Omega-3/Omega-6 Polyunsaturated Ratios with Dietary Fish Oils in Men with Prostate Cancer. Modulation of Omega-3/Omega-6 Polyunsaturated Ratios with Dietary Fish Oils in Men with Prostate Cancer. Urology. 2001 Aug;58(2):283-8.
Tymchuk CN, Barnard JR, Heber D, Aronson WJ. Evidence for an Inhibitory Effect of Diet and Exercise on Prostate Cancer Cell Growth. J Urol. 2001 Sep;166(3):1185-9.