Dr. Grace Xiao's group is interested in the regulation of gene expression at the RNA level via the process of pre-mRNA splicing and other post-transcriptional (or co-transcriptional) mechanisms. They are investigating how different sequence motifs and trans-acting regulatory RNA or proteins exert concerted regulation to gene expression and how such regulation is disrupted in disease processes. Their work makes use of high-throughput sequencing and microarray expression technologies and approaches in molecular biology and bioinformatics.
Selected Cancer-Related Publications:
Xiao X, Lee JH. Systems analysis of alternative splicing and its regulation. Wiley Interdiscip Rev Syst Biol Med. 2010 Sep-Oct;2(5):550-65.
Xiao X, Wang Z, Jang M, Nutiu R, Wang ET, Burge CB. Splice site strength-dependent activity and genetic buffering by poly-G runs. Nat Struct Mol Biol. 2009 Oct;16(10):1094-100. Epub 2009 Sep 13.
Xiao X, Wang Z, Jang M, Burge CB. Coevolutionary networks of splicing cis-regulatory elements. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18583-8. Epub 2007 Nov 12.