Dr. Jorge Torres studies mitotic spindle formation during cell division and how inhibiting cell division can be used in cancer treatment. His goal is to use large-scale RNA interference, small molecule and cDNA overexpression screens to identify either potential targets for anticancer drug treatment or small molecules that can be used as cancer therapeutics. He uses human cancer cell lines and in vitro systems along with a combination of approaches, including biochemistry, molecular biology, cell biology, chemical biology, and microscopy to determine the mechanism of action of these proteins and molecules.
Selected Cancer-Related Publications:
Torres JZ, Summers MK, Peterson D, Brauer MJ, Lee J, Senese S, Gholkar AA, Lo YC, Lei X, Jung K, Anderson DC, Davis DP, Belmont L, Jackson PK. The STARD9/Kif16a kinesin associates with mitotic microtubules and regulates spindle pole assembly. Cell. 2011 Dec 9;147(6):1309-23.
Torres JZ, Ban KH, Jackson PK. A specific form of phospho protein phosphatase 2 regulates anaphase-promoting complex/cyclosome association with spindle poles. Mol Biol Cell. 2010 Mar 15;21(6):897-904. Epub 2010 Jan 20.
Ban KH, Torres JZ, Miller JJ, Mikhailov A, Nachury MV, Tung JJ, Rieder CL, Jackson PK. The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis. Dev Cell. 2007 Jul;13(1):29-42.
Torres JZ, Schnakenberg SL, Zakian VA. Saccharomyces cerevisiae Rrm3p DNA helicase promotes genome integrity by preventing replication fork stalling: viability of rrm3 cells requires the intra-S-phase checkpoint and fork restart activities. Mol Cell Biol. 2004 Apr;24(8):3198-212.
Torres JZ, Bessler JB, Zakian VA. Local chromatin structure at the ribosomal DNA causes replication fork pausing and genome instability in the absence of the S. cerevisiae DNA helicase Rrm3p. Genes Dev. 2004 Mar 1;18(5):498-503.