Dr. Xinmin Li’s research focuses on the identification and characterization of genetic variations that affect complex diseases. Li takes an integrated genomic approach to examine the alteration of mRNA/miRNA expression, copy number variation, single nucleotide polymorphism and DNA-protein interaction by primarily using microarray-based technologies for initial screening and siRNA-mediated knockdown technologies for functional screening. His goals are to identify clinically significant genetic variations in several widely prevalent diseases including cancer and obesity. One of his ongoing research projects is to study the microRNA regulation of adipocyte differentiation. Using the combination of gene array/miRNA array profiling, bioinformatics and siRNA knockdown, Li and his colleagues have found that miR-17-92, a miRNA cluster that promotes cell proliferation in various cancers, can accelerate adipocyte differentiation by directly targeting a tumor suppressor, Rb2/p130.
Selected Cancer-Related Publications:
Schrump DS, Fischette MR, Nguyen DM, Zhao M, Li X, Kunst TF, Hancox A, Hong JA, Chen GA, Kruchin E, Wright JJ, Rosing DR, Sparreboom A, Figg WD, Steinberg SM. Clinical and molecular responses in lung cancer patients receiving Romidepsin. Clin Cancer Res. 2008 Jan 1;14(1):188-98.
Wang Q, Li YC, Wang J, Kong J, Qi Y, Quigg RJ, Li X. miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2889-94. Epub 2008 Feb 19.
Li X, Quigg RJ, Zhou J, Gu W, Nagesh Rao P, Reed EF. Clinical utility of microarrays: current status, existing challenges and future outlook. Curr Genomics. 2008 Nov;9(7):466-74.
Wang Q, Wang Y, Minto AW, Wang J, Shi Q, Li X, Quigg RJ. MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy. FASEB J. 2008 Dec;22(12):4126-35. Epub 2008 Aug 20.
Li X, Wang H, Touma E, Qi Y, Rousseau E, Quigg RJ, Ryaby JT. TP508 accelerates fracture repair by promoting cell growth over cell death. Biochem Biophys Res Commun. 2007 Dec 7;364(1):187-93. Epub 2007 Aug 22.