Dr. Anil Bhushan's laboratory research focuses on cell cycle regulation and epigenetic changes that regulate pancreatic beta cell formation and regeneration. His lab specifically focuses on epigenetic changes regulating gene expression involved in reprogramming pancreatic beta cells during organogenesis and islet regeneration. Understanding the epigenetic mechanisms that coordinate and maintain beta cell specific patterns of gene expression will provide a blueprint for deriving insulin-expressing cells from embryonic stem cells. His research is essential for developing therapeutic strategies to combat diabetes.
Selected Cancer-Related Publications:
Dhawan S, Tschen SI, Bhushan A. Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation. Genes Dev. 2009 Apr 15;23(8):906-11.
Zhong L, Georgia S, Tschen SI, Nakayama K, Nakayama K, Bhushan A. Essential role of Skp2-mediated p27 degradation in growth and adaptive expansion of pancreatic beta cells. J Clin Invest. 2007 Oct;117(10):2869-76.
Dhawan S, Georgia S, Bhushan A. Formation and regeneration of the endocrine pancreas. Curr Opin Cell Biol. 2007 Dec;19(6):634-45. Epub 2007 Dec 3. Review.
Georgia S, Bhushan A. p27 Regulates the transition of beta-cells from quiescence to proliferation. Diabetes. 2006 Nov;55(11):2950-6.
Georgia S, Bhushan A. Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest. 2004 Oct;114(7):963-8.