Scientific Interest(s):
Dr. Huan Meng’s research mainly focuses on nanomedicine and nanobiology. Meng plays a key role in the interdisciplinary Division of NanoMedicine at UCLA, including the safe design of a nanoparticle-based platform for anticancer drug and therapeutic siRNA delivery in cancer cells and intact animals. He is currently developing a list of particle design features that could successfully improve the utility of the multifunctional mesoporous silica nanoparticle platform that is being used for cargo molecules delivery, by controlling pore opening with variables including nanovalves, surface ligation modification and surface charge variation, and size and aspect ratio tuning. Meng also works for the Center for Environmental Implications of Nanotechnology (UC CEIN) at UCLA, where he and his colleagues study the safety of engineered nanomaterials, including the establishment of the link between biological outcomes and material properties that could lead to bio-compatible or bio-hazardous interactions in mammalian cells and animals.
Selected Cancer-Related Publications:
Meng H, Xue M, Xia T, Ji Z, Tarn DY, Zink JI, Nel AE. Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model. ACS Nano. 2011 May 24;5(5):4131-44. Epub 2011 Apr 27.
Meng H, Liong M, Xia T, Li Z, Ji Z, Zink JI, Nel AE. Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line. ACS Nano. 2010 Aug 24;4(8):4539-50.
Meng H, Xue M, Xia T, Zhao YL, Tamanoi F, Stoddart JF, Zink JI, Nel AE. Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves. J Am Chem Soc. 2010 Sep 15;132(36):12690-7.
Liang XJ, Meng H, Wang Y, He H, Meng J, Lu J, Wang PC, Zhao Y, Gao X, Sun B, Chen C, Xing G, Shen D, Gottesman MM, Wu Y, Yin JJ, Jia L. Metallofullerene nanoparticles circumvent tumor resistance to cisplatin by reactivating endocytosis. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7449-54. Epub 2010 Apr 5.
Meng H, Xia T, George S, Nel AE. A predictive toxicological paradigm for the safety assessment of nanomaterials. ACS Nano. 2009 Jul 28;3(7):1620-7.