Dr. Christiaan Schiepers is interested in multi-modality imaging in diagnostic oncology, with F-18 and C-11 labeled probes. The specific probes utilized are FDG, FLT, FDOPA, FAC, acetate and fluoride. Kinetic models for probes in humans were developed for FLT and FDOPA in glioma, Acetate in prostate cancer, and Fluoride in osteoporosis, Paget’s disease and osseous metastases. He has investigated and published dosimetry of a new family of FAC-probes in humans.
Selected Cancer-Related Publications:
Schiepers C, Dahlbom M, Chen W, Cloughesy T, Czernin J, Phelps ME, Huang SC. Kinetics of 3'-deoxy-3'-18F-fluorothymidine during treatment monitoring of recurrent high-grade glioma. J Nucl Med. 2010 May;51(5):720-7. doi: 10.2967/jnumed.109.068361. Epub 2010 Apr 15.
Schiepers C, Hoh CK, Nuyts J, Seltzer M, Wu C, Huang SC, Dahlbom M. 1-11C-acetate kinetics of prostate cancer. J Nucl Med. 2008 Feb;49(2):206-15. doi: 10.2967/jnumed.107.044453. Epub 2008 Jan 16.
Schiepers C, Chen W, Dahlbom M, Cloughesy T, Hoh CK, Huang SC. 18F-fluorothymidine kinetics of malignant brain tumors. Eur J Nucl Med Mol Imaging. 2007 Jul;34(7):1003-11. Epub 2007 Feb 13.
Schiepers C, Chen W, Cloughesy T, Dahlbom M, Huang SC. 18F-FDOPA kinetics in brain tumors. J Nucl Med. 2007 Oct;48(10):1651-61. Epub 2007 Sep 14.
Schiepers C, Haustermans K, Geboes K, Filez L, Bormans G, Penninckx F. The effect of preoperative radiation therapy on glucose utilization and cell kinetics in patients with primary rectal carcinoma. Cancer. 1999 Feb 15;85(4):803-11.