UCLA's Jonsson Comprehensive Cancer Center : JCCC Member Directory

Dino Di Carlo, Ph.D.

Affiliation(s):

Associate Professor, Department of Bioengineering

Member, California NanoSystems Institute

Member, JCCC Cancer Nanotechnology Program Area

Contact Information:

Phone:	(310) 983-3235
Email:	dicarlo@seas.ucla.edu
Website:	http://www.biomicrofluidics.com

Scientific Interest(s):

Dr. Dino Di Carlo’s research focuses on engineering of microfluidic and nanoparticle systems for the analysis of single cells for both improving cell-based diagnostics and automating cell biology. His group takes advantage of inertial fluid dynamic effects in particular to engineer simple systems for translational applications. Projects include:

measuring the mechanical properties of single cells at thousands of cells per second for label-free cancer screening
an automated cellular sample preparation instrument called the centrifuge-on-a-chip to prepare fluid samples from patients for improved cytological and molecular diagnostics
nanoparticle-based manipulation of intracellular environments using patterned magnetic substrates to study how local controlled signals contribute to cell response in normal and diseased cells.

Selected Cancer-Related Publications:

Gossett DR, Tse HT, Lee SA, Ying Y, Lindgren AG, Yang OO, Rao J, Clark AT, Di Carlo D. Hydrodynamic stretching of single cells for large population mechanical phenotyping. Proc Natl Acad Sci U S A. 2012 May 15;109(20):7630-5. Epub 2012 Apr 30.

Tse HT, Weaver WM, Di Carlo D. Increased asymmetric and multi-daughter cell division in mechanically confined microenvironments. PLoS One. 2012;7(6):e38986. Epub 2012 Jun 25.

Goda K, Ayazi A, Gossett DR, Sadasivam J, Lonappan CK, Sollier E, Fard AM, Hur SC, Adam J, Murray C, Wang C, Brackbill N, Di Carlo D, Jalali B. High-throughput single-microparticle imaging flow analyzer. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11630-5. Epub 2012 Jul 2.

Di Carlo D. A mechanical biomarker of cell state in medicine. J Lab Autom. 2012 Feb;17(1):32-42.

Mach AJ, Kim JH, Arshi A, Hur SC, Di Carlo D. Automated cellular sample preparation using a Centrifuge-on-a-Chip. Lab Chip. 2011 Sep 7;11(17):2827-34. Epub 2011 Jul 29.