Dr. Fang Wei’s research is currently focused on the real-time non-invasive monitoring of oncogenic mutations in human cancer patients by Electric Field Induced Release and Measurement (EFIRM). EFIRM is a multiplexing electrochemical sensor that integrates exosome isolation with on-chip exosomal biomarker release and measurement, and can detect and monitor progressive oncogene mutations in human cancer patients, in both circulatory and salivary exosomes. Specifically, Wei's lab is studying human EGFR mutations in lung cancer patients, and the preliminary research shows EFIRM technology can accurately detect two common EGFR mutations in paired malignant pleural effusion (MPE) and saliva exosome.
Selected Cancer-Related Publications:
Wei F, Wong DT. Point-of-care platforms for salivary diagnostics. Chin J Dent Res. 2012;15(1):7-15.
Wei F, Patel P, Liao W, Chaudhry K, Zhang L, Arellano-Garcia M, Hu S, Elashoff D, Zhou H, Shukla S, Shah F, Ho CM, Wong DT. Electrochemical sensor for multiplex biomarkers detection. Clin Cancer Res. 2009 Jul 1;15(13):4446-52. Epub 2009 Jun 9.
Wei F, Liao W, Xu Z, Yang Y, Wong DT, Ho CM. Bio/abiotic interface constructed from nanoscale DNA dendrimer and conducting polymer for ultrasensitive biomolecular diagnosis. Small. 2009 Aug 3;5(15):1784-90.
Lawi W, Wiita C, Snyder ST, Wei F, Wong D, Wong PK, Liao JC, Haake D, Gau V. A Microfluidic Cartridge System for Multiplexed Clinical Analysis. JALA Charlottesv Va. 2009 Dec 1;14(6):407-412.
Wei F, Wang J, Liao W, Zimmermann BG, Wong DT, Ho CM. Electrochemical detection of low-copy number salivary RNA based on specific signal amplification with a hairpin probe. Nucleic Acids Res. 2008 Jun;36(11):e65. Epub 2008 May 17.