Dr. Patrick Allard’s laboratory is using the nematode C. elegans to uncover mechanisms of germ cell maintenance and differentiation. By developing and applying novel genetic, cellular and molecular tools in the nematode, they attempt to 1) gain fast mechanistic insight on germline genes and pathways that are disrupted during environmental exposure and 2) comprehensively identify the germline signaling nodes that are environmentally sensitive.
Selected Cancer-Related Publications:
Allard P, Kleinstreuer N, Knudsen T, Colaiacovo MP. A screening platform for the rapid assessment of chemical disruption of germline function. Environ Health Perspect. 2013 (in press).
Allard P, Colaiacovo MP. Mechanistic insights into the action of Bisphenol A on the germline using C. elegans. Cell Cycle. 2011 Jan 15;10(2):183-4. Epub 2011 Jan 15.
Allard P, Colaiacovo MP. Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities. Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20405-10. doi: 10.1073/pnas.1010386107. Epub 2010 Nov 8.