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Steven Dubinett, M.D.
Steven Dubinett, M.D.


Pulmonary Disease

General Information:



Professor, Department of Pathology and Laboratory Medicine
Chief, Department of Medicine, Pulmonary and Critical Care Medicine
Member, ACCESS Department - Cellular and Molecular Pathology
Member, JCCC Cancer Nanotechnology Program Area
Member, JCCC Tumor Immunology Program Area

Hospital Affiliation(s):

Ronald Reagan UCLA Medical Center


Internal Medicine, Massachusetts General Hospital, 1985 - 1987
Internal Medicine, Veterans Administration Medical Center, 1981 - 1984
Internal Medicine, UMDNJ - University Hospital, 1980 - 1981
Medical Degree:
M.D., University of Medicine and Dentistry of NJ, 1980


Board Certification(s):
Critical Care Medicine, American Board of Internal Medicine, 1991
Pulmonary Disease, American Board of Internal Medicine, 1988
Internal Medicine, American Board of Internal Medicine, 1983

Contact Information:

(310) 825-8061 Pulmonary and Critical Care Medicine information and referral

Scientific Interest(s):

Dr. Steven Dubinett's research encompasses several areas of translational investigation in lung cancer. The primary focus of study assesses the impact of tumor cyclooxygenase 2 (COX-2) in lung cancer. He and his colleagues are investigating COX-2-dependent gene and protein expression and determining how these modify tumor invasion, angiogenesis, immunity and apoptosis in non-small cell lung cancer (NSCLC). Identification of COX-2 dependent gene regulation will allow the researchers to define new biomarkers in the COX-2 inhibitor-mediated antitumor response. Novel genes and pathways for future targeted therapies are also being identified and studied.

Selected Cancer-Related Publications:

Cui X, Zhang L, Luo J, Rajasekaran A, Hazra S, Cacalano N, Dubinett SM. Unphosphorylated STAT6 contributes to constitutive cyclooxygenase-2 expression in human non-small cell lung cancer. Oncogene. 2007; 26(29): 4253-60.

Hazra S, Batra RK, Tai HH, Sharma S, Cui X, Dubinett SM. Pioglitazone and rosiglitazone decrease prostaglandin E2 in non-small-cell lung cancer cells by up-regulating 15-hydroxyprostaglandin dehydrogenase. Mol Pharmacol. 2007; 71(6): 1715-20.

Lee JM, Mao JT, Krysan K, Dubinett SM. Significance of cyclooxygenase-2 in prognosis, targeted therapy and chemoprevention of NSCLC. Future Oncol. 2007; 3(2): 149-53.

Liu M, Yang SC, Sharma S, Luo J, Cui X, Peebles KA, Huang M, Sato M, Ramirez RD, Shay JW, Minna JD, Dubinett SM. EGFR Signaling is Required for TGF-{beta}1-mediated COX-2 Induction in Human Bronchial Epithelial Cells. Am J Respir Cell Mol Biol. 2007.

Lu QY, Jin YS, Zhang ZF, Le AD, Heber D, Li FP, Dubinett SM, Rao JY. Green tea induces annexin-I expression in human lung adenocarcinoma A549 cells: involvement of annexin-I in actin remodeling. Lab Invest. 2007; 87(5): 456-65.