Three committees oversee clinical research within UCLA's Jonsson Comprehensive Cancer Center (JCCC): the Internal Scientific Peer Review Committee (ISPRC), Quality Assurance Committee (QAC) and Data Safety Monitoring Board (DSMB).
ISPRC
The ISPRC was constituted in 1993 to provide rigorous internal scientific peer review for all clinical oncology protocols conducted by JCCC investigators. Drs. Robert Elashoff and John Glaspy serve as the Chairman and Vice-Chairman, respectively, of the ISPRC. Under their direction, the committee reviews the required elements of the clinical protocol, statistical applications and other factors such as adequate research staffing, any competing trials, well-constituted data collection forms and utilization of other JCCC resources.
ISPRC application forms are available for download below. Please note that only these forms will be accepted beginning September 1, 2008.
DSMB
In response to the National Cancer Institute mandate, the JCCC DSMB was constituted in January 2001 and meets monthly. The JCCC DSMB reviews all Serious Adverse Events (SAEs) occurring in JCCC protocols. In addition, the JCCC DSMB serves as the DSMB for institutional research studies at UCLA that do not have an external DSMB. The JCCC DSMB helps to ensure that adequate safety monitoring will be carried out for all cancer interventional trials offered at the JCCC. The DSMB oversees the implementation of the data monitoring plans approved by ISPRC and on file with the JCCC. The chairman of the JCCC DSMB is Dr. Sven De Vos.
IQAP
JCCC has had a long-standing internal quality assurance program, beginning in 1986, to ensure proper conduct of clinical trials in oncology and, in so doing, safeguarding the rights and welfare of the study subjects. The internal compliance program is responsible for establishing an effective mechanism to promote proper adherence to all applicable local, state and federal laws, as well as specific program or cooperative group requirements by all researchers involved in oncology clinical research. The IQAP includes:
- Performance of prospective monitoring and retrospective auditing of active trials to ensure regulatory and protocol compliance.
- Ensuring proper patient management per protocol and to ensure patient safety.
- Assisting principal investigators, sub-investigators and all clinical trial study team members by consulting on problems identified during any monitoring or auditing reviews.
- Educating and continually updating the research community regarding clinical research requirements.
Submissions
Please submit all applications to the Office of Regulatory Compliance:
On Campus:
JCCC Office of Regulatory Compliance
8-684 Factor Building
Mailcode: 178121
Off Campus:
700 Tiverton Ave.
8-684 Factor Building
Box 951781
Los Angeles, CA 90095-1781
Contact Information
- Main Office: (310) 794-8742
- Terra Hughes, M.S., Administrative Director
(310) 206-5775
- Sujna Raval-Fernandes, Ph.D., Clinical Research Compliance Officer
(310) 794-8693
- Shaun Mason, Human Research Support Coordinator
(310) 267-2475
- Manoa Hui, Administrative Specialist
(310) 794-8742