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UCLA Acquires Tool That Delivers Higher Doses of Radiation in Less Time
Posted Date: 3/30/2009

Dr. Michael SteinbergDr. Percy LeeUCLA has added a new tool to its cancer-fighting arsenal, a state-of-the-art image-guided device that provides more accurate, concentrated doses of radiation, allowing patients to be treated in fewer visits and suffer from fewer side effects.

UCLA’s Department of Radiation Oncology is the first center in the Los Angeles area to install Novalis Tx, a non-invasive stereotactic radiosurgery machine that includes three imaging modalities. The modalities track the location of tumors during respiration and other movement and allow physicians to pinpoint the tumor and position the patient so the radiation is delivered with the highest precision to the cancerous tissue while protecting the healthy surrounding tissues.

The Novalis Tx has an advanced system that continuously shapes the radiation beam to mirror the tumor’s size and dimensions as it rotates around the patient delivering treatment from different angles. In addition, the platform holding the patient moves not only side to side and up and down, but also rotates around a vertical axis.

Physicians using the machine likened it to a high-performance sports car with all the bells and whistles that make such a vehicle desirable.

“This Novalis Tx is like having a really nice BMW. With it, you get all the basic features of stereotactic radiosurgery, but you also get all these amazing, high-tech accessories,” said Dr. Percy Lee, an assistant professor of radiation oncology at UCLA and the director of the stereotactic body radiation therapy (SBRT) program, which will employ the Novalis Tx to treat localized tumors. “This machine has state-of-the-art features like the multiple imaging modalities to cover every clinical circumstance and make it more precise and accurate.”

In some cases, Novalis Tx can reduce needed radiation from daily treatments for six weeks to just three to five days because of the high doses that can be delivered using the SBRT approach, Lee said. This results in less radiation dose to the neighboring normal tissues, sparing side effects while also improving tumor control rates.

The device will be used to treat cancers of the brain, spine, lung, liver, pancreas, prostate and kidney. Because the radiation is so precisely aimed, Novalis Tx also will allow patients that may have inoperable, untreatable tumors to receive therapy they might not otherwise have been given.

The technology’s precision also will enable UCLA physicians to employ Novalis Tx to address a number of medical conditions unrelated to cancer. For example, the beam can be directed to pinpoint nerves responsible for causing severe facial pain and muscle spasms in trigeminal neuralgia. It also can target arteriovenous malformations, or AVMs, abnormal tangles of blood vessels that prevent oxygenated blood from reaching and nourishing tissue. Depending on their location in the body, some AVMs are otherwise inoperable.

Michael Selch, a professor of radiation oncology, said Novalis Tx offered several advantages over the current technology, but what caught UCLA’s attention was an upgrade to the multileaf collimator, the mechanism that controls the continuous shaping of the radiation beam as it enters the patient from different angles.

“It allows us to shape the dose and target tumors very precisely to protect normal tissues,” said Selch, a specialist in central nervous system radiation oncology. “It helps us to be more efficient, accurate and rapid in targeting stereotactic body radiation therapy to tissues such as the lung and liver, where movement with respiration is a problem. Novalis Tx will open up new avenues of radiosurgery for us, allowing us to treat even difficult-to-plan tumors with unusual shapes.”

In late 2008, Beverly Namnoun, 63, of Long Beach, suffered a recurrence of lung cancer first diagnosed in 2007. Although her tumor was still small - a good sign - because of its location near her airway, esophagus and spinal cord, she would not otherwise have been a candidate for radiation. But she recently underwent her first treatment with Novalis Tx, which delivered the dose without harming her nearby tissues.

“UCLA is known for being on the leading-edge of technology. That’s why I wanted to be treated there. I think it’s exciting to be getting this new technology,” Namnoun said after undergoing her first treatment. “It was quick and I didn’t feel a thing.”

Lee, who is Namnoun’s radiation oncologist, said her tumor presented challenges, but with the advanced technology available now, he believes she has a good prognosis.

“With its advanced accuracy, Novalis Tx will improve our therapeutic ratio between controlling the cancer and minimizing side effects,” said Lee, who also is a researcher with UCLA’s Jonsson Comprehensive Cancer Center. “It also will provide us with daily verifications that we’re keeping our radiation beam to the intended tumor target. This is especially important because Beverly also has scleroderma, a systemic disease that may possibly pre-dispose her to more normal tissue radiation side effects.”

In addition to the advanced technology of Novalis Tx, UCLA’s radiation oncology department employs a multi-disciplinary care approach to ensure patients get the best treatment. Using computers and specialized software, physicists create an individual treatment plan for each patient based on their tumor’s size and shape. Technicians, nurses and radiation oncologists work together to treat the patient.

“It’s like that fancy car,” Lee said. “If you don’t have a good driver, all the bells and whistles don’t matter. It’s just a machine that’s fancy. At UCLA, we have the top experts from all the disciplines driving this machine. Our patients are in excellent hands.”

UCLA has led the charge in the use of Novalis technology. In 1998, the radiation oncology department installed the first Novalis machine in the world. Initially, it was used only to treat brain tumors, but later expanded to other cancers in the body. In all, more than 4,000 cancer patients have been treated using the original machine.

“We have an incredible amount of experience using this type of machine,” said Dr. Michael Steinberg, chairman of radiation oncology and a Jonsson Cancer Center scientist. “That will aid us in treating the most difficult cases.”

UCLA's Jonsson Comprehensive Cancer Center has more than 350 researchers and clinicians engaged in disease research, prevention, detection, control, treatment and education. One of the nation's largest comprehensive cancer centers, the Jonsson center is dedicated to promoting research and translating basic science into leading-edge clinical studies. In July 2008, the Jonsson Cancer Center was named among the top 10 cancer centers nationwide by U.S. News & World Report, a ranking it has held for nine consecutive years. For more information on the Jonsson Cancer Center, visit our website at http://www.cancer.ucla.edu.

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