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JCCC Member Directory

Michael Irwin, M.D.
Michael Irwin, M.D.



General Information:



Professor in Residence, Department of Psychiatry and Biobehavioral Sciences
Member, JCCC Patients and Survivors Program Area


Psychiatry, UCLA School of Medicine, 1982 - 1985
Internal Medicine, UC San Diego School of Medicine, 1981 - 1982
Medical Degree:
M.D., UCSD School of Medicine, 1981


Board Certification(s):
Psychiatry, American Board of Psychiatry and Neurology, 1987

Contact Information:

(310) 825-8281
(310) 825-9989 Information and referral [(800) 825-9989 from outside 310]

Scientific Interest(s):

Dr. Michael Irwin's principal research interests focus on the mechanisms of neuroimmune interactions and the impact of PNI processes on disease including infectious disease, rheumatoid arthritis, cardiovascular disease and substance dependence. He has been the principal investigator of 14 federally funded research awards, including five currently active research awards from the National Institute of Mental Health, National Institute of Alcoholism and Alcohol Abuse, National Institute of Aging, National Institute of Arthritis, and Musculoskeletal Disorders and the National Institute of Drug Abuse.

Irwin's current research topics include "Alcoholism: Sleep and Cytokines in African-Americans," "Depression and Trial of Varicella Vaccine in the Elderly" and "Behavioral Intervention for Herpes Zoster Risk in Aging."

Selected Cancer-Related Publications:

Irwin MR, Olmstead RE, Ganz PA, Haque R. Sleep disturbance, inflammation and depression risk in cancer survivors. Brain Behav Immun. 2013 Mar;30 Suppl:S58-67. Epub 2012 May 24

Bower JE, Garet D, Sternlieb B, Ganz PA, Irwin MR, Olmstead R, Greendale G. Yoga for persistent fatigue in breast cancer survivors: a randomized controlled trial. Cancer. 2012 Aug 1;118(15):3766-75. Epub 2011 Dec 16

Bower JE, Ganz PA, Irwin MR, Kwan L, Breen EC, Cole SW. Inflammation and behavioral symptoms after breast cancer treatment: do fatigue, depression, and sleep disturbance share a common underlying mechanism? J Clin Oncol. 2011 Sep 10;29(26):3517-22. Epub 2011 Aug 8

Bower JE, Ganz PA, Irwin MR, Arevalo JM, Cole SW. Fatigue and gene expression in human leukocytes: increased NF-kappaB and decreased glucocorticoid signaling in breast cancer survivors with persistent fatigue. Brain Behav Immun. 2011 Jan;25(1):147-50. Epub 2010 Sep 18

Miller AH, Ancoli-Israel S, Bower JE, Capuron L, Irwin MR. Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer. J Clin Oncol. 2008 Feb 20;26(6):971-82.