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Jonathan Braun, M.D., Ph.D.
Jonathan Braun, M.D., Ph.D.



General Information:



Professor and Chair, Department of Pathology and Laboratory Medicine, Surgical Pathology
Physician, Department of Pathology and Laboratory Medicine, Surgical Pathology
Professor, Department of Molecular and Medical Pharmacology
Co-Director, JCCC Tumor Immunology Program Area

Hospital Affiliation(s):

Ronald Reagan UCLA Medical Center


Pathology, Brigham and Women's Hospital, 1982 - 1983
Pathology and Laboratory Medicine, Brigham and Women's Hospital, 1981
Medical Degree:
M.D., Harvard Medical School, 1981
Ph.D., Harvard Medical School, 1980

Contact Information:

(310) 794-7953
(310) 267-2680 (Outreach Client Services)
(310) 825-8947 (Surgical Pathology Reports)

Scientific Interest(s):

Dr. Jonathan Braun's research is focused on the molecular basis of disease-related immune processes. Innate and adaptive immune functions play a major role in susceptibility to and outcome of infectious diseases, autoimmunity and cancer.

Braun's laboratory is devoted to the molecular basis of disease-related immune processes in two areas. Normal intestinal physiology requires peaceful cohabitation of abundant colonic bacteria with the epithelial and immune components of the intestinal mucosa. His laboratory's goals are to understand the cellular and molecular basis of bacterial-immune homeostasis in the gut, and how these insights can explain the pathogenesis and guide the treatment of inflammatory bowel disease. Presently, he and his colleagues are studying the surprising role of intestinal B lymphocytes and CD8 T-cells in prevention of genetic models of mouse colitis, with a focus on their developmental biology and the role of G-coupled and bacterial sensing receptor systems in this process.

Molecules involved in cytotoxic lymphocyte interaction with tumor cells are central to the mechanism and therapeutic strategies of anti-tumor immunity. Braun's current work focuses on the biochemistry and cell biology of the EMP2 subfamily of tetraspan proteins, because of their fundamental role in the intracellular trafficking and surface display of receptors associated with non-caveolin lipid raft domains. His translational research efforts are devoted to immunologic imaging using positron emission tomography (PET) to refine the CTL targeting strategies, and developing early paths to their potential clinical applications.

Selected Cancer-Related Publications:

Yamamoto ML, Maier I, Dang AT, Berry D, Liu J, Ruegger PM, Yang JI, Soto PA, Presley LL, Reliene R, Westbrook AM, Wei B, Loy A, Chang C, Braun J, Borneman J, Schiestl RH. Intestinal bacteria modify lymphoma incidence and latency by affecting systemic inflammatory state, oxidative stress, and leukocyte genotoxicity. Cancer Res. 2013 Jul 15;73(14):4222-32. doi: 10.1158/0008-5472.CAN-13-0022.

McHardy IH, Goudarzi M, Tong M, Ruegger PM, Schwager E, Weger JR, Graeber TG, Sonnenburg JL, Horvath S, Huttenhower C, McGovern DPB, Fornace Jr. AJ, Borneman J and Braun J. Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter-relationships. Microbiome.2013, 1:17. Epub 2013 May 13. DOI: 10.1186/2049-2618-1-17.

Presley LL, Ye J, Li X, Leblanc J, Zhang Z, Ruegger PM, Allard J, McGovern D, Ippoliti A, Roth B, Cui X, Jeske DR, Elashoff D, Goodglick L, Braun J, Borneman J. Host-microbe relationships in inflammatory bowel disease detected by bacterial and metaproteomic analysis of the mucosal-luminal interface. Inflamm Bowel Dis. 2012 Mar;18(3):409-17. doi: 10.1002/ibd.21793. Epub 2011 Jun 22.

Fu M, Rao R, Sudhakar D, Hogue CP, Rutta Z, Morales S, Gordon LK, Braun J, Goodglick L, Wadehra M. Epithelial membrane protein-2 promotes endometrial tumor formation through activation of FAK and Src. PLoS One. 2011;6(5):e19945. doi: 10.1371/journal.pone.0019945. Epub 2011 May 27.

Wei B, Wingender G, Fujiwara D, Chen DY, McPherson M, Brewer S, Borneman J, Kronenberg M, Braun J. Commensal microbiota and CD8+ T cells shape the formation of invariant NKT cells. J Immunol. 2010 Feb 1;184(3):1218-26. doi: 10.4049/jimmunol.0902620. Epub 2010 Jan 4.