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Larry Simpson, Ph.D.
Larry Simpson, Ph.D.


Professor, Department of Microbiology, Immunology and Molecular Genetics
Member, JCCC Cancer and Stem Cell Biology Program Area

Contact Information:

(310) 825-4215

Scientific Interest(s):

The trypanosomes or kinetoplastid protozoa comprise a large group of parasitic flagellated cells that are the causal agents for a variety of human and animal diseases. Research in Dr. Larry Simpson's laboratory has focused on the molecular biology of the mitochondrial genome in these organisms from several points of view. These cells represent one of the earliest eukaryotic lineages containing mitochondria and, as such, possess many unusual physical and biochemical features, among which is a mitochondrial genome known as "kinetoplast DNA" that consists of a network of thousands of catenated mini- and maxi-circles, transcripts of which are modified by a novel process termed "RNA editing."