Dr. Larry Zipursky's research focuses on the molecular mechanism regulating neuronal connection specificity. To approach this issue, Zipursky and his colleagues have been studying the formation of connections in the fruit fly brain. The fruit fly is well suited to the identification of mutants in which connection specificity is disrupted. The researchers can easily visualize the patterns of connections made by different neurons and manipulate these cells genetically.
Selected Cancer-Related Publications:
Nern A, Nguyen LV, Herman T, Prakash S, Clandinin TR, Zipursky SL. An isoform-specific allele of Drosophila N-cadherin disrupts a late step of R7 targeting. Proc Natl Acad Sci U S A. 2005; 102(36): 12944-9.
Hummel T, Zipursky SL. Afferent induction of olfactory glomeruli requires N-cadherin. Neuron. 2004; 42(1): 77-88.
Zhan XL, Clemens JC, Neves G, Hattori D, Flanagan JJ, Hummel T, Vasconcelos ML, Chess A, Zipursky SL. Analysis of Dscam diversity in regulating axon guidance in Drosophila mushroom bodies. Neuron. 2004; 43(5): 673-86.
Hummel T, Vasconcelos ML, Clemens JC, Fishilevich Y, Vosshall LB, Zipursky SL. Axonal targeting of olfactory receptor neurons in Drosophila is controlled by Dscam. Neuron. 2003; 37(2): 221-31.
Lee RC, Clandinin TR, Lee CH, Chen PL, Meinertzhagen IA, Zipursky SL. The protocadherin Flamingo is required for axon target selection in the Drosophila visual system. Nat Neurosci. 2003; 6(6): 557-63.