Dr. Marcos Paiva's research focuses on the laser and chemotherapy for denaturation of cancer cells, including improving Nd:YAG laser thermal therapy for patients with recurrent head and neck cancer. With continuous funding from the National Cancer Institute (NIH) for the past 17 years, this translational study has progressed introducing a novel experimental treatment for cancer based on the concept of high doses of intratumor injections of chemotherapy (cisplatin) combined with localized infra-red hyperthermia.
Selected Cancer-Related Publications:
Paiva MB, Joo J, Abrahao M, Ribeiro JC, Cervantes O, Sercarz JA. Update on laser photochemotherapy: an alternative for cancer treatment. Anticancer Agents Med Chem. 2011 Oct;11(8):772-9.
Sercarz JA, Bublik M, Joo J, Paiva PB, Areco KN, Brandalise MH, Loh C, Masterman-Smith M, Paiva MB. Outcomes of laser thermal therapy for recurrent head and neck cancer. Otolaryngol Head Neck Surg. 2010 Mar;142(3):344-50.
Joo J, Sercarz JA, Paolini AA, Castro DJ, Paiva MB. Laser-induced thermal therapy and cisplatin for recurrent head and neck cancer: a case characterized by an unusually long disease-free survival. Ear Nose Throat J. 2009 Nov;88(11):E13-6.
Kanekal S, Joo J, Bublik M, Bababeygy A, Loh C, Castro DJ, Sercarz JA, Paiva MB. Retention of intratumor injections of cisplatinum in murine tumors and the impact on laser thermal therapy for cancer treatment. Eur Arch Otorhinolaryngol. 2009 Feb;266(2):279-84. Epub 2008 Jul 8.
Paiva MB, Saxton RE, Blackwell KE, Buechler P, Cohen A, Liu CD, Calcaterra TC, Ward PH, Castro DJ. Combined cisplatinum and laser thermal therapy for palliation of recurrent head and neck tumors. Diagn Ther Endosc. 2000;6(3):133-40.