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Jau-Nian Chen, Ph.D.
Jau-Nian Chen, Ph.D.


Associate Professor, Department of Molecular, Cell, and Developmental Biology
Member, ACCESS Department - Molecular, Cell, and Developmental Biology
Member, JCCC Cancer and Stem Cell Biology Program Area

Contact Information:

(310) 206-4513

Scientific Interest(s):

Dr. Jau-Nian Chen's laboratory is investigating the development of the cardiovascular system in zebrafish. She and her colleagues are employing both genetic and molecular approaches to identify genes that are responsible for cell-fate determination, proliferation and differentiation of cardiovascular precursors, as well as the patterning of the heart and vessels.

Several unique features make zebrafish ideal for genetic and embryological studies. For instance, the transparent nature of zebrafish embryos provides easy access to observe and study organ development in live embryos. Chen and his colleagues generated transgenic zebrafish lines in which cardiac or vascular progenitor cells are marked by the expression of Green Fluorescent Protein (GFP). The researchers are using these transgenic fish to conduct genetic screens to identify new mutations affecting the patterning and function of the cardiovascular system. They are currently focusing on phenotypic characterization of mutations affecting the size and the rhythm of the heart and the patterning of cardiac chambers and vessels. Chen and her colleagues are also doing positional cloning to identify genes that are responsible for these phenotypes.

Selected Cancer-Related Publications:

Cibri?n-Uhalte E, Langenbacher A, Shu X, Chen JN, Abdelilah-Seyfried S. Involvement of zebrafish Na+,K+ ATPase in myocardial cell junction maintenance. J Cell Biol. 2007; 176(2): 223-30.

Choi J, Dong L, Ahn J, Dao D, Hammerschmidt M, Chen JN. FoxH1 negatively modulates flk1 gene expression and vascular formation in zebrafish. Dev Biol. 2007; 304(2): 735-44.

Liu J, Fraser SD, Faloon PW, Rollins EL, Vom Berg J, Starovic-Subota O, Laliberte AL, Chen JN, Serluca FC, Childs SJ. A {beta}Pix-Pak2a signaling pathway regulates cerebral vascular stability in zebrafish. Proc Natl Acad Sci U S A. 2007.

Lu G, Ren S, Korge P, Choi J, Dong Y, Weiss J, Koehler C, Chen JN, Wang Y. A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development. Genes Dev. 2007; 21(7): 784-96.

Shu X, Huang J, Dong Y, Choi J, Langenbacher A, Chen JN. Na,K-ATPase alpha2 and Ncx4a regulate zebrafish left-right patterning. Development. 2007; 134(10): 1921-30.