Scientific Interest(s):
Dr. Shimon Weiss's research focuses on single molecule biophysics, particularly the application of single molecule spectroscopy: to biology and nanotechnology, dynamic structural biology, conformational dynamics of molecular machines, protein folding, protein-DNA and protein-protein interactions, single molecule enzymology, ultrahigh resolution & ultrahigh sensitivity fluorescence microscopy and spectroscopy and the physics and chemistry of mesoscopic (nano-scale) systems.
Selected Cancer-Related Publications:
Bentolila LA, Weiss S. Single-step multicolor fluorescence in situ hybridization using semiconductor quantum dot-DNA conjugates. Cell Biochem Biophys. 2006; 45(1): 59-70.
Jager M, Nir E, Weiss S. Site-specific labeling of proteins for single-molecule FRET by combining chemical and enzymatic modification. Protein Sci. 2006; 15(3): 640-6.
Doose S, Tsay JM, Pinaud F, Weiss S. Comparison of photophysical and colloidal properties of biocompatible semiconductor nanocrystals using fluorescence correlation spectroscopy. Anal Chem. 2005; 77(7): 2235-42.
Jager M, Michalet X, Weiss S. Protein-protein interactions as a tool for site-specific labeling of proteins. Protein Sci. 2005; 14(8): 2059-68.
Kapanidis AN, Margeat E, Laurence TA, Doose S, Ho SO, Mukhopadhyay J, Kortkhonjia E, Mekler V, Ebright RH, Weiss S. Retention of transcription initiation factor sigma70 in transcription elongation: single-molecule analysis. Mol Cell. 2005; 20(3): 347-56.