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Albert Lai, M.D., Ph.D.
Albert Lai, M.D., Ph.D.



General Information:



Associate Professor in Residence, Department of Neurology, Neuroscience Graduate Program
Professor, Brain Research Institute
Physician, Department of Neurology
Co-Chair, Protocol Review and Monitoring System (PRMS)
Member, JCCC Signal Transduction and Therapeutics Program Area

Hospital Affiliation(s):

Ronald Reagan UCLA Medical Center


Neurology, UCLA School of Medicine, 2002
Medical Degree:
M.D., University of California at San Diego, 1998
Ph.D., University of California at San Diego, 1996


Board Certification(s):
Neurology, American Board of Psychiatry and Neurology, 2004

Contact Information:

(310) 825-5321
(310) 794-1195 Neurology information and patient appointments

Scientific Interest(s):

Dr. Albert Lai's research interest is in understanding the role of Connexin43, the primary astrocytic gap junction, in the growth and migration of glioma cells. These studies are being conducted in cell culture using a model system of overexpression of wild-type and mutant Connexin 43 constructs in rat C6 glioma cells. He is also beginning studies examining the role of promoter methylation of MGMT and response to temozolomide. These studies involve analysis of methylation of genomic DNA isolated from human tissue collected during glioblastoma resection. These initial studies will form the basis for broader inquiry regarding the role of epigenetic alterations on glioblastoma initiation and progression.

Selected Cancer-Related Publications:

Carlson M, Pope WB, Horvath S, Braunstein JG, Nghiemphu P, Tso CL, Mellinghoff I, Lai A, Liau LM, Mischel P, Nelson SF, Cloughesy T. Relationship between survival and edema in malignant gliomas: role of VEGF and neuronal pentraxin 2. Clin. Canc. Research. 2007; 13:2592-2598.

Chen W, Delaloye S, Geist C, Silverman DH, Czernin J, Sayre J, Satyamurthy N, Pope WB, Lai A, Cloughesy T. Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with 18F-FLT PET: a pilot study. J. Clin Oncology. accepted, 2007.

Lai A, Le D, Paznekas WA, Gifford WD, Jabs EW, Charles AC. Oculodentodigital dysplasia connexin43 mutations result in non-functional connexin hemichannels and gap junctions in C6 glioma cells. J. Cell Sci. 2006; 119:532-541.

Pope WB, Lai A, Nghiemphu P, Mischel P, Cloughesy T. MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy. Neurology. 2006; 66(8):1258-1260.