UCLA's Jonsson Comprehensive Cancer Center : JCCC Member Directory

Osvaldo Rey, Ph.D.

Affiliation(s):

Adjunct Associate Professor, Department of Medicine, Digestive Diseases

Member, JCCC Signal Transduction and Therapeutics Program Area

Contact Information:

Phone:	(310) 794-5902
Email:	orey@mednet.ucla.edu

Scientific Interest(s):

Dr. Osvaldo Rey is interested in the mechanisms that regulate the intracellular distribution of DAG-dependent serine/threonine kinases in response to GPCR stimulation, as well as the signaling pathways regulated by the calcium sensing receptor.

Selected Cancer-Related Publications:

Rey O, Young SH, Papazyan R, Shapiro M, and Rozengurt E. Requirement of the TRPC1 cation channel in the generation of transient Ca 2+ oscillations by the calcium sensing receptor. The Journal of Biochemistry. 2006; 281:38730-37.

Rey O, Papazyan R, Waldron RT, Lippincott-Schwartz J, Jacamo R, Rozengurt E. The nuclear import of protein kinaseD3 requires its catalytic activity. The Journal of Biochemistry. 2005; 281:5149-57.

Rey O, Young S, Yuan J, Slice L, Rozengurt E. Amino acid-stimulated Ca 2+ oscillations produced by the Ca 2+ sensing receptor are mediated by a phospholipase C/inositol 1,4,5-triphosphate-independent pathway that requires G12, Rho filamin-A, and the actin cytoskeleton. J Biol Chem. 2005 Jun 17;280(24):22875-82. Epub 2005 Apr 18.

Rey O, Reeve JR, Zhukova E, Sinnett-Smith J, Rozengurt E. G protein-coupled receptor-mediated phosphorylation of the activation loop of protein kinase D: dependence on plasma membrane translocation and protein kinase Cepsilon. J Biol Chem. 2004; 279(33): 34361-72.

Rey O, Yuan J, Young SH, Rozengurt E. Protein kinase Cnu/PKD3 nuclear localization, catalytic activation and intercellular redistribution in response to G protein-coupled receptor agonists. The Journal of Biochemistry. 2003; 278:23773-85.