The focal research points of Dr. Caius Radu's lab are the development of novel positron emission tomography (PET) probes to image T-lymphocyte activation and inflammation, the evaluation of cancer immunotherapy using PET reporter gene approaches; and the development of non-immunogenic PET reporter gene systems.
Selected Cancer-Related Publications:
Bailey RC, Kwong GA, Radu CG, Witte ON, Heath JR. DNA-Encoded Antibody Libraries: A Unified Platform for Multiplexed Cell Sorting and Detection of Genes and Proteins. J Am Chem Soc. 2007; 129(7): 1959-1967.
Radu CG, Cheng D, Nijagal A, Riedinger M, McLaughlin J, Yang LV, Johnson J, Witte ON. Normal immune development and glucocorticoid-induced thymocyte apoptosis in mice deficient for the T-cell death-associated gene 8 receptor. Mol Cell Biol. 2006; 26(2): 668-77.
Radu CG, Nijagal A, McLaughlin J, Wang L, Witte ON. Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. Proc Natl Acad Sci U S A. 2005; 102(5): 1632-7.
Shu CJ, Guo S, Kim YJ, Shelly SM, Nijagal A, Ray P, Gambhir SS, Radu CG, Witte ON. Visualization of a primary anti-tumor immune response by positron emission tomography. Proc Natl Acad Sci U S A. 2005; 102(48): 17412-7.
Radu CG, Yang LV, Riedinger M, Au M, Witte ON. T cell chemotaxis to lysophosphatidylcholine through the G2A receptor. Proc Natl Acad Sci U S A. 2004; 101(1): 245-50.