Dr. Henry Huang's research focuses on the delivery, transport, metabolism and receptor binding of labeled compounds and drugs in local tissue regions in vivo, using the methodologies of quantitative PET, tracer kinetics and modeling. Tracer kinetic models are formulated and validated based on experimental biochemical information. Based on the validated models, practical study procedures and reliable estimation techniques are developed to obtain quantitative biological information in vivo in humans. Major emphasis is on the understanding of basic mechanisms related to the uptake, clearance and metabolism of labeled compounds under various conditions. Biological parameters studied include blood perfusion, glucose utilization rate, oxygen consumption rate, dopamine D2 receptor density and fluoroDOPA decarboxylation rate.
Selected Cancer-Related Publications:
Schiepers C, Chen W, Dahlbom M, Cloughesy T, Hoh CK, Huang SC. (18)F-fluorothymidine kinetics of malignant brain tumors. Eur J Nucl Med Mol Imaging. 2007.
Kesner AL, Dahlbom M, Huang SC, Hsueh WA, S Pio B, Czernin J, Kreissl M, Wu HM, Silverman DH. Semiautomated analysis of small-animal PET data. J Nucl Med. 2006; 47(7): 1181-6.
Huang SC, Truong D, Wu HM, Chatziioannou AF, Shao W, Wu AM, Phelps ME. An internet-based"kinetic imaging system" (KIS) for MicroPET. Mol Imaging Biol. 2005; 7(5): 330-41.
Huang SC, Wu HM, Shoghi-Jadid K, Stout DB, Chatziioannou A, Schelbert HR, Barrio JR. Investigation of a new input function validation approach for dynamic mouse microPET studies. Mol Imaging Biol. 2004; 6(1): 34-46.