Dr. Henry Huang's research focuses on the delivery, transport, metabolism and receptor binding of labeled compounds and drugs in local tissue regions in vivo, using the methodologies of quantitative PET, tracer kinetics and modeling. Tracer kinetic models are formulated and validated based on experimental biochemical information. Based on the validated models, practical study procedures and reliable estimation techniques are developed to obtain quantitative biological information in vivo in humans. Major emphasis is on the understanding of basic mechanisms related to the uptake, clearance and metabolism of labeled compounds under various conditions. Biological parameters studied include blood perfusion, glucose utilization rate, oxygen consumption rate, dopamine D2 receptor density and fluoroDOPA decarboxylation rate.
Selected Cancer-Related Publications:
Wardak M, Schiepers C, Dahlbom M, Cloughesy T, Chen W, Satyamurthy N, Czernin J, Phelps ME, Huang SC. Discriminant analysis of ¹8F-fluorothymidine kinetic parameters to predict survival in patients with recurrent high-grade glioma. Clin Cancer Res. 2011 Oct 15;17(20):6553-62. Epub 2011 Aug 25
Wong KP, Sha W, Zhang X, Huang SC. Effects of administration route, dietary condition, and blood glucose level on kinetics and uptake of 18F-FDG in mice. J Nucl Med. 2011 May;52(5):800-7. Epub 2011 Apr 15
Schiepers C, Dahlbom M, Chen W, Cloughesy T, Czernin J, Phelps ME, Huang SC. Kinetics of 3'-deoxy-3'-18F-fluorothymidine during treatment monitoring of recurrent high-grade glioma. J Nucl Med. 2010 May;51(5):720-7. Epub 2010 Apr 15
Pan MH, Huang SC, Liao YP, Schaue D, Wang CC, Stout DB, Barrio JR, McBride WH. FLT-PET imaging of radiation responses in murine tumors. Mol Imaging Biol. 2008 Nov-Dec;10(6):325-34. Epub 2008 Aug 1
Ferl GZ, Zhang X, Wu HM, Kreissl MC, Huang SC. Estimation of the 18F-FDG input function in mice by use of dynamic small-animal PET and minimal blood sample data. J Nucl Med. 2007 Dec;48(12):2037-45. Epub 2007 Nov 15