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David Dawson, M.D., Ph.D.
David Dawson, M.D., Ph.D.



General Information:



Associate Professor, Department of Pathology and Laboratory Medicine
Physician, Department of Pathology and Laboratory Medicine, Surgical Pathology, Gastroenterology/Liver Pathology
Member, JCCC Signal Transduction and Therapeutics Program Area

Hospital Affiliation(s):

UCLA Medical Center, Santa Monica
Ronald Reagan UCLA Medical Center


Anatomic Pathology, UCLA School of Medicine, 2000 - 2001
Anatomic and Clinical Pathology, UCLA School of Medicine, 1999 - 2000
Medical Degree:
M.D., Northwestern University Medical School, 1999
Ph.D., Northwestern University, 1997


Board Certification(s):
Anatomic Pathology, American Board of Pathology, 2002

Contact Information:

(310) 794-9450 Gastroenterology/Liver and Surgical Pathology information and referral
(310) 267-2680 Gastroenterology/Liver Pathology referring physician

Scientific Interest(s):

Dr. David Dawson is interested in molecular changes responsible for the development and progression of pancreatic adenocarcinoma. His primary research is focused on the regulation and function of Wnt signaling in pancreatic cancer progression with the long term goals of developing clinically useful Wnt-based biomarkers and therapeutic strategies. He is also seeking to understand the spectrum of epigenetic events causally linked to pancreatic tumorigenesis, as well as the factors responsible for dictating changes in DNA methylation and post-translational histone modifications during pancreatic tumor initiation and progression.

Selected Cancer-Related Publications:

Arensman MD, Kovochich AN, Kulikauskas RM, Lay AR, Yang PT, Li X, Donahue T, Major MB, Moon RT, Chien AJ, Dawson DW. NT7B mediates autocrine Wnt/Beta-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma. Oncogene. 2013 Feb 18. doi: 10.1038/onc.2013.23. [Epub ahead of print]

Dawson DW, Hertzer K, Moro A, Donald G, Chang HH, Go VL, Pandol SJ, Lugea A, Gukovskaya AS, Li G, Hines OJ, Rozengurt E, Eibl G. High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model. Cancer Prev Res (Phila). 2013 Oct;6(10):1064-73. doi: 10.1158/1940-6207.CAPR-13-0065. Epub 2013 Aug 13.

Nguyen Kovochich A, Arensman M, Lay AR, Rao NP, Donahue T, Li X, French SW, Dawson DW. HOXB7 promotes invasion and predicts survival in pancreatic adenocarcinoma. Cancer. 2013 Feb 1;119(3):529-39. doi: 10.1002/cncr.27725. Epub 2012 Aug 22.

Donahue TR, Tran LM, Hill R, Li Y, Kovochich A, Calvopina JH, Patel SG, Wu N, Hindoyan A, Farrell JJ, Li X, Dawson DW, Wu H. Integrative survival-based molecular profiling of human pancreatic cancer. Clin Cancer Res. 2012 Mar 1;18(5):1352-63. doi: 10.1158/1078-0432.CCR-11-1539. Epub 2012 Jan 18.

Manuyakorn A, Paulus R, Farrell J, Dawson NA, Tze S, Cheung-Lau G, Hines OJ, Reber H, Seligson DB, Horvath S, Kurdistani SK, Guha C, Dawson DW. Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: results from RTOG 9704. J Clin Oncol. 2010 Mar 10;28(8):1358-65. doi: 10.1200/JCO.2009.24.5639. Epub 2010 Feb 8.